We consider the numerical solution of the wave equation in a two-dimensional domain and start from a boundary integral formulation for its discretization. We employ the convolution quadrature (CQ) for the temporal and a Galerkin boundary element method (BEM) for the spatial discretization. Our main focus is the sparse approximation of the arising sequence of boundary integral operators by panel...

sandwich panel with central core honeycomb aluminum as one of the main shielding structures because of their high strength-to-weight ratio and improved energy absorption capacity, has been attracted the attention of many researchers and practitioners in recent years. this paper initiates and presents a new type of central core honeycomb formed by hydroforming process. the study is augmented by ...

A method is proposed to identify the mechanical properties of the skin and core materials of sandwich structures having heterogeneous cores. All the elastic coefficients and loss-factors that matter in the dynamics of such a panel in the thick-plate approximation are identified. To this end, experimental natural modes (i.e. eigenmodes of the damped system) are compared to the numerical modes of...

ARF, NPM and FOXM1 proteins interact with each other in mammalian cells. We showed previously that proteasome inhibitors suppress not only FOXM1 expression, but also the expression of ARF and NPM proteins. Using RNA interference we found that the depletion of each of these proteins by RNAi in human cancer HeLa cells leads to down-regulation of the two other partners, suggesting that these prote...

This paper uses mixed methods to examine the impact of New Public Management (NPM) on public sector nurses’ perceptions of workplace autonomy and, in turn, their job satisfaction. The quantitative findings of this study suggest that nurses’ perception of autonomy does moderate their job satisfaction. The qualitative findings suggest that the implementation of NPM has negatively affected nurses’...

This paper reports an in-depth and longitudinal case study on the new public management (NPM) reforms introduced in Portuguese public hospitals throughout the 2000s. The objectives of the investigation were twofold: firstly, it sought to analyse the role of accounting technologies and market-based mechanisms in the NPM reforms introduced in the sector when compared with other cases of NPM imple...

Telomerase activation and telomere maintenance are critical for cellular immortalization and transformation. PIN2/TERF1-interacting telomerase inhibitor 1 (PinX1) is a telomerase regulator and the aberrant expression of PinX1 causes telomere shortening. Identifying PinX1-interacting proteins is important for understanding telomere maintenance. We found that PinX1 directly interacts with nucleop...

Various cellular stresses activate autophagy, which is involved in lysosomal degradation of cytoplasmic materials for maintaining nutrient homeostasis and eliminating harmful components. Here, we show that RNA polymerase I (Pol I) transcription inhibition induces nucleolar disruption and autophagy. Treatment with autophagy inhibitors or siRNA specific for autophagy-related (ATG) proteins inhibi...

This study aims to determine the effect of dividend policy on stock prices pharmaceutical sub-sector manufacturing companies Indonesia Stock Exchange; NPM Exchange, and both together Exchange. The population in this are that carry out policies net profit margins for 2016-2020 period by selecting samples using purposive sampling method so a sample five is taken. research uses literature document...

Anaplastic large cell lymphoma (ALCL) exhibiting the t(2;5) translocation is characterized by the resulting expression of the oncogenic fusion protein nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) gene product. The ALK domain of NPM-ALK contains kinase activity, which is responsible for the autophosphorylation of tyrosine residues of the oncogenic protein and phosphorylation of SH2-protein...