High-density polyethylene (HDPE) piping has been used in place of steel alloys in the petrochemical, power, and mining industries due to its exceptional resistance to corrosion and erosion. Recently, HDPE has also been used for nuclear safety-related cooling water applications. The application of nuclear quality assurance requirements creates reasonable assurance that the production fusion join...

A small tokamak-based fusion reactor can be attractive for actinide waste transmutation. Equilibrium concentrations of transuranium isotopes were estimated in a molten-salt based fusion transmutation reactor. Nuclear performance parameters were derived for two types of fusion-driven transmutation reactors: Pu-assisted and minor actinidesonly systems. The minor actinide-only burning system appea...

RNA helicase A (RHA) undergoes nuclear translocation via a classical import mechanism utilizing karyopherin beta. The nuclear transport domain (NTD) of RHA is known to be necessary and sufficient for its bi-directional nuclear trafficking. We report here that arginine methylation is a novel requirement for NTD-mediated nuclear import. Nuclear translocation of glutathione S-transferase (GST)-NTD...

Nuclear segmentation is an important step for profiling aberrant regions of histology sections. However, segmentation is a complex problem as a result of variations in nuclear geometry (e.g., size, shape), nuclear type (e.g., epithelial, fibroblast), and nuclear phenotypes (e.g., vesicular, aneuploidy). The problem is further complicated as a result of variations in sample preparation. It is sh...

During the mating of yeast Saccharomyces cerevisiae, two haploid nuclei fuse to produce a diploid nucleus. This process requires the functions of BiP/Kar2p, a member of the Hsp70 family in the endoplasmic reticulum, and its partner protein, Jem1p. To investigate further the role of BiP and Jem1p in nuclear fusion, we screened for partner proteins for Jem1p by the yeast two-hybrid system and ide...

Nucleocytoplasmic exchange of nuclear hormone receptors is hypothesized to allow for rapid and direct interactions with cytoplasmic signaling factors. In addition to recycling between a naïve, chaperone-associated cytoplasmic complex and a liganded chaperone-free nuclear form, the glucocorticoid receptor (GR) has been observed to shuttle between nucleus and cytoplasm. Nuclear export of GR and o...

An innovative computational tool (DAG-MCNP) has been developed for efficient and accurate 3-D nuclear analysis of geometrically complex fusion systems. Direct coupling with CAD models allows preserving the geometrical details, eliminating possible human error, and faster design iterations. DAG-MCNP has been applied to perform 3-D nuclear analysis for several fusion designs and demonstrated the ...