Folic acid fortification of grain foods on a mandatory basis has been in place in the USA since 1998. Because of the safety concerns surrounding this issue, the Food and Drug Administration in the USA, responsible for implementing the new fortification legislation, opted for the relatively low folic acid concentration of 1400mg/kg product, (United States Department of Health and Human Services,...

Tensor decomposition is used for many web and user data analysis operations from clustering, trend detection, anomaly detection, to correlation analysis. However, many of the tensor decomposition schemes are sensitive to noisy data, an inevitable problem in the real world that can lead to false conclusions. The problem is compounded by overfitting when the user data is sparse. Recent research h...

NMDA receptors (NMDARs) are heteromeric assemblies of NR1 and NR2(A-D) subunits with properties heavily influenced by the type of NR2 subunit incorporated. While NMDARs with only one type of NR2 subunit have been extensively characterized, little is known about receptors containing two different NR2 subunits, despite compelling evidence that such triheteromeric receptors exist in vivo. We used ...

The mechanism for low temperature electrical conduction in neutron transmutation doped (NTD) germanium is believed to be variable range hopping (VRH). The resistance, R, at temperature T should then follow R(T ) = R0 exp (T0/T ) p, for constant (or nearly constant) values of T0, R0 and p. NTD Ge is thought to have a “Coulomb gap” in the density of states; theories then generally predict p = 0.5...

Ribonucleotide reductase maintains cellular deoxyribonucleotide pools and is thus tightly regulated during the cell cycle to ensure high fidelity in DNA replication. The Sml1 protein inhibits ribonucleotide reductase activity by binding to the R1 subunit. At the completion of each turnover cycle, the active site of R1 becomes oxidized and subsequently regenerated by a cysteine pair (CX2C) at it...

Hormone therapies for advanced prostate cancer target the androgen receptor (AR) ligand-binding domain (LBD), but these ultimately fail and the disease progresses to lethal castration-resistant prostate cancer (CRPC). The mechanisms that drive CRPC are incompletely understood, but may involve constitutively active AR splice variants that lack the LBD. The AR N-terminal domain (NTD) is essential...

Background: Inhibition of the androgen receptor (AR) is mainstay treatment for advanced prostate cancer. While initially effective, disease ultimately progresses to metastatic castration-resistant cancer (mCRPC), which lethal. All current AR-targeted therapies directly or indirectly target ligand binding domain (LBD). We have developed EPI and sintokamide (SINT) compounds AR N-terminal (NTD), a...