DT40 cells have approx. 10-fold higher Mg2+-dependent neutral sphingomyelinase (NSM) activity in comparison with other B-cell lines and contain very low acidic sphingomyelinase activity. Purification of this activity from DT40 cell membranes suggested the presence of one major NSM isoform. Although complete purification of this isoform could not be achieved, partially purified fractions were ex...

The effects of smoking cigarettes with 30% of the tobacco replaced by NSM tobacco substitute, which lowered their tar and nicotine delivery, were studied by comparing them with the effects of conventional cigarettes in a controlled crossover trial lasting 20 months. Chest symptoms, cigarette consumption, and forced expiratory volume in one second (FEV1) were measured each month. Two-hundred men...

Background/Aims Post-operative ileus (POI) is a common complication of abdominal surgery. DA-9701, an extract of Pharbitis Semen and Corydalis Tuber, is a new prokinetic agent that also alleviates visceral pain. The aim of this study was to investigate whether DA-9701 can ameliorate POI in rats. Methods A total of 32 rats were divided into 4 groups: no surgery/no medication (NSNM), no surgery...

Several solutions have been developed to provide dataintensive applications with the highest possible data rates. Such solutions tried to utilize the available network resources through parallel I/O and TCP/IP tuning in order to achieve a better data throughput. The focus was on achieving the highest possible data rate while other performance enhancements factors were ignored. Furthermore, most...

This article proposes a hybrid Particle Swarm Optimization (PSO) based on the Nonlinear Simplex Method (NSM). At late stage of PSO running, when the promising regions of solutions have been located, the algorithm isolates particles which are very close to the extrema and applies the NSM to them to enhance the local exploitation. Experimental results on several benchmark functions demonstrate th...

RESULTS: Reconstruction was achieved without any failure or NAC losses in all 40/40 breasts, 20 bilateral targeted two stage risk reducing mastopexy/reduction and NSM/ SIR procedures. Patients median BMI was 30(22–44). Six patients were smokers and one had hypertension. Anatomical shaped silicone implants were used in all cases, average size 555 cc, (310 to 690). Average OR time for NSM/ SIR wa...

The present research deals with the review of the analysis and modeling of Swiss franc interest rate curves (IRC) by using unsupervised (SOM, Gaussian Mixtures) and supervised machine (MLP) learning algorithms. IRC are considered as objects embedded into different feature spaces: maturities; maturity-date, parameters of Nelson-Siegel model (NSM). Analysis of NSM parameters and their temporal an...

However, not all women are candidates for the operation. From an oncologic perspective, NSM is limited to women with small, early stage peripheral cancers [1, 2]. From a plastic surgery perspective, the NSM is typically offered to women with small breasts and minimal ptosis. The large breasted woman with significant ptosis faces risks with this operation, including NAC and skin necrosis due to ...

hydroxyapatite (ha) nano-rods with uniform morphology and controllable size have been successfully synthesized in the presence of cationic and non-ionic surfactants by a hydrothermal method. (nh4) 2hpo4 and ca(no 3)2.4h2o were used as the phosphorus and calcium sources, respectively. the composition of synthesized powders was characterized using x-ray diffraction, and fourier transform infrared...

I would like to begin by briefly reviewing the assumptions and hypotheses the NSM approach is predicated on. The goal of this exercise is to understand how these are interrelated, what hinges on every one of them, and what consequences arise from discarding an assumption or disproving a hypothesis. This process defines a number of projects which all agree up to some point and then depart. Prima...