The genus Streptomyces produces secondary metabolic compounds that are rich in biological activity. Many of these compounds are genetically encoded by large secondary metabolism biosynthetic gene clusters (smBGCs) such as polyketide synthases (PKS) and non-ribosomal peptide synthetases (NRPS) which are modular and can be highly repetitive. Due to the repeats, these gene clusters can be difficul...

The detection of pain in persons with advanced dementia is challenging due to their inability verbally articulate the they are experiencing. Pain Assessment Advanced Dementia (PAINAD) an observer-rated assessment tool developed based on non-verbal expressions for severe dementia. This study aimed perform construct validation PAINAD Malaysia. was a prospective cross-sectional conducted from 27 A...

Here, we describe the draft genome sequence of Actinoplanes utahensis NRRL 12052, a filamentous bacterium that encodes an aculeacin A acylase and a putative N-acyl-homoserine lactone acylase of biotechnological interest. Moreover, several nonribosomal peptide synthase (NRPS) and polyketide synthase (PKS) clusters and antibiotic resistance genes have been identified.

The draft genome sequence of Saccharomonospora sp. strain LRS4.154, a moderately halophilic actinobacterium, has been determined. The genome has 4,860,108 bp, a G+C content of 71.0%, and 4,525 open reading frames (ORFs). The clusters of PKS and NRPS genes, responsible for the biosynthesis of a large number of biomolecules, were identified in the genome.

Abstract Purpose Wheat sheath blight mainly infected by Rhizoctonia cerealis is one of the soil-borne fungal diseases wheat worldwide and prevalent in major growing areas China at present. This study aimed to evaluate antifungal activity 163 endophytic fungi on R. . Antifungal strains were identified their biosynthetic potential was analysed. Methods The evaluated via dual-culture antagonism as...