An efficient and operationally simple synthesis of fluoroalkanes by deoxygenative hydrofluorination of carbonyl compounds via their tosylhydrazone surrogates is reported. The reaction can be carried out in a one-pot procedure directly from carbonyl compounds.

We present a methodology for solving the inverse-quantitative structure-activity relationship (QSAR) problem using the molecular descriptor called signature. This methodology is detailed in four parts. First, we create a QSAR equation that correlates the occurrence of a signature to the activity values using a stepwise multilinear regression technique. Second, we construct constraint equations,...

Recent advances in the palladium-catalyzed remote functionalization of carbonyl derivatives are highlighted in this review. The structure of the article is based on the three strategies that have emerged in recent years as the most viable tactics to construct C(sp(3))-C, C(sp(3))-N or C(sp(3))-O bonds at a distance of at least three carbon atoms from the carbonyl functionality. The specific asp...

in production of tissue paper, the adhesion of a liquid adhesive creping aid, compound polymer, as creping aids on the yankee dryer surface was investigated. a compound polymer was prepared based on mixing ratio of poly (amideamine)-epichlorohydrin resin (pae) as an adhesive agent, polyvinyl alcohol (pva) as a modifier agent, and cationic fatty acid (cfa) and ethylene glycol (eg) as release age...

in the present study, anti-anaphylactic, anti-inflammatory and membrane stabilizing properties of a lupine alkaloid plumerianine (compound 1), isolated from the root bark of plumeria acutifolia poir were investigated in animal models. the anti-anaphylactic activity of compound 1 (10, 25 and 50 mg/kg) was studied by using models such as passive cutaneous anaphylaxis, passive paw anaphylaxis and ...

calotropis gigantea (linn) and amoora rohituka (roxb.) have long been used in folkloric medicine for the treatment of various ailments in bangladesh. the present study was designed to investigate the cytotoxicity of isolated compounds from these two plants. two compounds, named β-boswellic acid (compound-1) and 2-methoxy-14-calamenenone (compound-2) were isolated from the flowers of calotropis ...

derivatives of pyridine-4-one are iron chelators with various biological activities including antifungal, anti-malarial, antiviral, anti-inflammatory and analgesic activities. this study was aimed to evaluate the analgesic effect of four new derivatives of 3-hydroxy pyridine-4-one in animal models. acetic acid-induced writhing and formalin tests were used to assess the analgesic activity in mal...

background: regarding the strong differentiation and anti-leukemic activity of dendrostellera lessertii extract, an active agent with similar capabilities was isolated from the crude extract of the plant leaves. the aim of this study was to determine whether the anti-proliferative effect observed for this compound, is differentiation-dependent among the drug-treated cells, using u937 cells. met...