PURPOSE To determine the functional defects in two male patients with progressive cone dystrophy and hybrid L-M cone pigment genes. METHODS Clinical evaluation, standard electroretinography, and electrooculography were performed in two affected patients and two family members. Measurements of spectral sensitivity and transient tritanopia were made in both patients. RESULTS In the patients, ...

PURPOSE. To study the relationship between macular cone structure, fundus autofluorescence (AF), and visual function in patients with Stargardt disease (STGD). METHODS. High-resolution images of the macula were obtained with adaptive optics scanning laser ophthalmoscopy (AOSLO) and spectral domain optical coherence tomography in 12 patients with STGD and 27 age-matched healthy subjects. Measure...

BACKGROUND Local anaesthetics exhibit direct neurotoxic effects on neurones. Numerous studies have investigated the factors that may reverse this neuropathology, but the effects of glucose conditions on neuronal regeneration after lidocaine-induced injury have not been examined by observing living neurones. The present study investigated the effects of different glucose conditions on neurite le...

PURPOSE This study examines a patient with cone-rod dystrophy using high-resolution adaptive optics retinal imaging. Conventional ophthalmoscopes provide limited resolution due to their inability to overcome the eye's optical aberrations. In contrast, adaptive optics ophthalmoscopes correct these aberrations to provide noninvasive high-resolution views of the living retina. To date, adaptive op...

Rayleigh match data were modeled with the aim of explaining the locations of match midpoints and matching ranges, both in normal trichromats and in subjects with congenital color deficiency. Model parameters included the wavelength of peak sensitivity of cone photopigments, the effective photopigment optical density, and the noise amplitude in the red-green color channel. In order to avoid the ...

Linking the activity of neurons, circuits and synapses to human behavior is a fundamental goal neuroscience. Meeting this challenging, in part because behavior, particularly perception, often masks complexity underlying neural circuits, significant behavioral differences between primates animals like mice flies which genetic manipulations are relatively common. Here we relate circuit-level proc...

The retina of anamniotes (fish and amphibia), unlike the CNS of most vertebrates, can regenerate neurons following injury. Using the highly ordered mosaic of single and double cones in the retina of the adult green sunfish (Lepomis cyanellus) as our model system, we examined the events that followed the surgical excision of a small patch of central retina. After surgery there was a transient el...

PURPOSE To perform a detailed clinical, psychophysical, and molecular assessment of members of 4 families with an unusual X-linked cone dysfunction syndrome associated with myopia. PARTICIPANTS Affected and unaffected members of 4 British nonconsanguineous families. METHODS Subjects underwent both detailed clinical examination and psychophysical testing. After informed consent was obtained,...

Computational knot theory and 3-manifold topology have seen significant breakthroughs in recent years, despite the fact that many key algorithms have complexity bounds that are exponential or greater. In this setting, experimentation is essential for understanding the limits of practicality, as well as for gauging the relative merits of competing algorithms. In this paper we focus on normal sur...

The appearance of a particular object depends on both the viewpoint from which it is observed and the light sources by which it is illuminated. If the appearance of two objects is never identical for any pose or lighting conditions, then { in theory { the objects can always be distinguished or recognized. The question arises: What is the set of images of an object under all lighting conditions ...