Pituitary adenomas (PA) constitute about 10% of intracranial neoplasm. Most of them have its origin in adenohypophysis (Cury et al., 2009; Rosai, 1989). They occur most often in adults between the ages of 30 and 60 years, and may have slightly higher incidence in females in early life (20-45 years) and in males in later life (35-60 years) (Davis et al., 2001; McDowell et al., 2011). The majorit...

Pituitary adenomas are among the most frequent intracranial neoplasms and treatment depends on tumor subtype and clinical features. Unfortunately, non responder cases occur, then new molecular targets are needed. Notch system component expression and activation data are scarce in pituitary tumorigenesis, we therefore aimed to characterize Notch system in pituitary tumors of different histotype....

Pituitary adenomas are very common in humans. They are of monoclonal origin, very heterogeneous, and produce frequently paradoxical secretion. The normal anterior pituitary (AP) contains some unorthodox multifunctional cells able to store more than one AP hormone (polyhormonal) and/or to express multiple hypothalamic-releasing hormone receptors (multiresponsive). Multifunctional AP cells seem t...

OBJECTIVE The expression of transcription factors involved in early pituitary development, such as PROP1 and POU1F1, has been detected in pituitary adenoma tissues. In this study, we sought to characterize the transcriptional profiles of PROP1, POU1F1, and TBX19 in functioning and nonfunctioning pituitary adenomas in an attempt to identify their roles in tumorigenesis and hormone hypersecretion...

Neural transdifferentiation is increasingly recognized in neural crest and neural stem cell tumors. Neuronal differentiation has been anecdotally described primarily in somatotroph cell adenomas associated with acromegaly, but its prevalence in adenomas and relationship to adenoma type has not been completely established. In this study we performed a retrospective morphological and immunohistoc...

The pituitary gonadotropic adenoma is an developed́ in the cells of anterior pituitary. It can be secreting releasing excess blood and urine; products its secretion are gonadostimulines (F.S.H. L.H.) or non-secreting this case only histo- cytochemical analysis will able to allow identification. We report two cases macroadenoma with LH-FSH immunostaining. Pituitary magnetic resonance imaging reve...

A tumoral mass at the clivus is uncommon and its differential diagnosis presents a challenge, since many different tumours may result in a similar radiological image. A chordoma is the most common of these tumours and represents 40% of all cases. Less common, in decreasing order of frequency, are meningiomas, astrocytoma, germinal cell tumours, lymphoma, metastases and, finally, pituitary adeno...

Reliable data on familial risks are important for clinical counseling and cancer genetics. We wanted to study incidence trends and familial risks for pituitary adenomas and associated tumors through parental and sibling probands, using the nation-wide Swedish Family-Cancer Database on 10.5 million individuals, containing families with parents and offspring. Cancer data were retrieved from the S...

Pituitary tumors are rare in childhood and adolescence, with a reported prevalence of up to 1 per million children. Although pituitary tumors are rare in childhood and adolescence, and are typically histologically benign, significant morbidity may result due to their location, mass effect, and/or interference with normal pituitary hormone functions. The frequency of macro adenomas and aggressiv...

Pituitary adenomas and craniopharyngiomas are similar in some aspects. Usually, they both are histologically benign, slow-growing intracranial tumors that arise in the sellar and parasellar areas, and tend to cause similar symptoms and signs, such as, but not limited to, progressive visual loss, progressive endocrine problems, and headache. They both are likely to have an excellent prognosis if...