The current study examined motor timing in frontotemporal dementia (FTD), which manifests as progressive deterioration in social, behavioural and cognitive functions. Twenty-patients fulfilling consensus clinical criteria for behavioural variant FTD (bvFTD), 11 patients fulfilling consensus clinical criteria for semantic-variant primary progressive aphasia (svPPA), four patients fulfilling crit...

Difficulties with temporal coordination or sequencing of speech movements are frequently reported in aphasia patients with concomitant apraxia of speech (AOS). Our major objective was to investigate the effects of specific rhythmic-melodic voice training on brain activation of those patients. Three patients with severe chronic nonfluent aphasia and AOS were included in this study. Before and af...

We use computational techniques to extract a large number of different features from the narrative speech of individuals with primary progressive aphasia (PPA). We examine several different types of features, including part-of-speech, complexity, context-free grammar, fluency, psycholinguistic, vocabulary richness, and acoustic, and discuss the circumstances under which they can be extracted. W...

Melodic Intonation Therapy (MIT) involves involves patients with nonfluent aphasia intoning (singing) melodic phrases while tapping syllables. Thus, MIT incorporates the musical components of both pitch and rhythm. This critical review explores the relative contribution of the rhythmic and pitch components of MIT to determine if both components are required for success. To explore this question...

OBJECTIVE To present patients with stuttering speech in association with stroke. DESIGN Case series with follow-up for 5 years, or until the stuttering resolved. SETTING University and community hospital neurology wards, and ambulatory neurology clinics. PATIENTS Four patients who developed stuttering speech in association with an acute ischemic stroke. A 68-year-old man acutely developed...

Introduction Melodic Intonation Therapy (MIT) 1 is based on the observation that persons with severe nonfluent aphasia are often able to sing words or even short phrases they cannot produce during speech. MIT uses the melodic elements of speech, such as intonation and rhythm, to facilitate and improve language production. Although clinicians disagree about the usefulness of MIT, it has been tra...

OBJECTIVE Motor speech disorders are believed to be uncommon in early Alzheimer's disease (AD). However, data from maximum performance tests of motor speech function in AD and related disorders are virtually nonexistent. The aim of this study was to make such data available. MATERIALS AND METHODS Sequential speech motion rate was analyzed in 236 memory clinic patients with different levels of...

Nematodes and insects are the two most speciose animal phyla and nematode-insect associations encompass widespread biological interactions. To dissect the chemical signals and the genes mediating this association, we investigated the effect of an oriental beetle sex pheromone on the development and behavior of the nematode Pristionchus pacificus. We found that while the beetle pheromone is attr...

The title compound, {[Zn(C(14)H(16)N(5)O(3))(2)]·2H(2)O}(n) or [Zn(ppa)(2)]·2H(2)O}(n), where ppa = 8-ethyl-5,8-dihydro-5-oxo-2-(1-piperazin-yl)-pyrido(2,3-d)-pyrimidine-6-carboxyl-ate, was synthesized under hydro-thermal conditions. The Zn(II) atom (site symmetry ) exhibits a distorted trans-ZnN(2)O(4) octa-hedral geometry defined by two monodentate N-bonded and two bidentate O,O-bonded ppa mo...