4Winge, 0., and Roberts, C., Comp. Rend. Trav. Lab., Carlsb., Ser. Physiol., 24, 263-315 (1948). 5 Ryan, F. J., and Schneider, L. K., Genetics, 34, 72-91 (1949). 6 Luria, S. E., and Delbruck, M., Ibid., 28, 491-511 (1943). 7Mundkur, B., and Lindegren, C. C., Am. J. Botany, 36, 722-727 (1949). 8 Lea, D. E., and Coulson, C. A., J. Genetics, 49, 264-285 (1949). 9Spiegelman, S., Cold Spring Harbor ...

T4 lysozyme was thought to destroy bacteria by its muramidase activity. However, we demonstrate here that amphipathic helix stretches in the C-terminus of T4 lysozyme mediate its bactericidal and fungistatic activities. In heat-denatured T4 lysozyme, the enzymatic activity is completely abolished but unexpectedly, the antimicrobial functions remain preserved. Small synthetic peptides correspond...

RNA non-enzymatic recombination reactions are of great interest within the hypothesis of the "RNA world", which argues that at some stage of prebiotic life development proteins were not yet engaged in biochemical reactions and RNA carried out both the information storage task and the full range of catalytic roles necessary in primitive self-replicating systems. Here we report on the study of re...

D mellitus (DM) is associated with a greatly increased risk of secondary complications, such as cutaneous manifestations, myocardial infarction, nephropathy, retinopathy, and polyneuropathy. The non-enzymatic glycation of proteins followed by the formation of advanced glycation end products (AGEs) plays an important role in the pathology of diabetic complications.1 Occasionally endocrinological...