Allergic diseases are manifest as intestinal (GI) tract. This hyperresponsiveness may have both IgE-mediated and non-IgE-mediated components (Fig. 4). The situation is further complicated because allergen exposure in allergic subjects may increase target organ hyperresponsiveness, which results in exaggerated symptoms on exposure to nonspecific irritants (tobacco smoke, changes in temperature, ...

Purpose: The incidence of persistent rhinitis in childhood is increasing day by day. Since bronchial hyperreactivity (BHR) and asthma can also be seen a significant proportion patients with rhinitis, the use markers that may indicate risk developing these very important clinical follow-up. In this study, it was aimed to demonstrate relationship between using methacoline challenge test (BMCT) in...

Background Failure in oral tolerance induction causes allergic sensitization, but the mechanism behind this is still not fully understood. Previously, we found that the number of intraepithelial lymphocytes (IEL, including gammadelta T cells) was decreased during allergic sensitization. In addition, modulation of gammadelta T cells by a specific antibody resulted in enhanced allergic sensitizat...

microRNAs are a class of small, non-coding RNAs that regulate the expression of a diverse array of genes and pathways, with important roles in disease pathogenesis. Many of these microRNAs are currently under investigation as biomarkers or therapeutic options in a range of diseases. Here, we discuss the role of microRNAs in allergic diseases, allergic asthma, allergic rhinitis and atopic dermat...

Background As a non-invasive parameter of lower airway inflammation, fraction of exaled nitric oxide (FeNO) concentration has been known to be related with bronchial hyperreactivity in asthma patient. FeNO may be increased in atopy related diseases (e.g. allergic rhinitis) but relationship of FeNO and development of allergic rhinitis in asthma is unknown. The aim of this study was to investigat...

BACKGROUND The prevalence of eczema varies markedly across the globe. It is unclear whether the geographic variation is due to race and/or ethnic differences, environmental exposures, or genetic factors. OBJECTIVE We investigated the effects of ethnicity and environmental exposures on eczema in Hispanic white and non-Hispanic white children who participated in the Southern California Children...

BACKGROUND Past evidence has suggested a role of artificial sweeteners in allergic disease; yet, the evidence has been inconsistent and unclear. OBJECTIVE To examine relation of intake of artificially-sweetened beverages during pregnancy with child asthma and allergic rhinitis at 18 months and 7 years. METHODS We analyzed data from 60,466 women enrolled during pregnancy in the prospective l...