Abstract Non‐alcoholic steatohepatitis (NASH) and alcohol‐associated (ASH) are the major cause of liver‐related mortality with limited therapeutic options available. In this study, we investigated role Src tyrosine kinase in pathogenesis (N)ASH. We examined expression livers from patients NASH, ASH, cirrhosis biliary atresia, preclinical mouse models: methionine choline deficient (MCD)‐diet‐ind...

Prevalence of non-alcoholic steatohepatitis (NASH) rises steadily in Western countries with the obesity epidemic. NASH is associated with activation of liver fibrogenesis and predisposes to cirrhosis and associated morbi-mortality. The cannabinoid system is increasingly emerging as a crucial mediator of acute and chronic liver injury. Recent experimental and clinical data indicate that peripher...

The authors summarize and update the most recent knowledge in the field of prevalence, natural history and incidence of Non Alcoholic Fatty Liver Disease (NAFLD) and Non Alcoholic Steatohepatitis (NASH). These novel diseases, firstly recognized at the beginning of the second millennium, arose suddenly to the attention of the clinicians, because they are the hepatic expression of the "so-called"...

In the last years, there has been extremely much information which reveals an alarming increase of obesity in children and, at the same time, an increase of the incidence of non-alcoholic fatty liver disease (NAFLD). NAFLD implies a wide range of affections starting from simple hepatic steatosis to non-alcoholic steatohepatitis (NASH); the latter can evolve to cirrhosis and hepatic carcinoma. A...

Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in the world, yet the complex pathogenesis remains to be fully elucidated. The prevalence of NAFLD has risen precipitously in recent years and is now a leading indication for liver transplantation. New waitlist registrants with non-alcoholic steatohepatitis-induced cirrhosis increased by 170% from 2004 t...

Non-alcoholic fatty liver disease (NAFLD) is becoming increasingly prevalent due to the worldwide obesity epidemic and currently affects one-third of adults or about one billion people worldwide. NAFLD is predicted to affect over 50% of the world's population by the end of the next decade. It is the most common form of liver disease and is associated with increased risk for progression to a mor...

CONTEXT Nonalcoholic Fatty Liver Disease (NAFLD) is the major chronic liver disease in the pediatric population. NAFLD includes a broad spectrum of abnormalities (inflammation, fibrosis and cirrhosis), ranging from accumulation of fat (also known as steatosis) towards non-alcoholic steatohepatitis (NASH). The development of NAFLD in children is significantly increased. EVIDENCE ACQUISITION A ...

Non-alcoholic fatty liver disease is the most prevalent with a global prevalence of 25%. The frequency non-alcoholic and percentage people severe are expected to rise given ongoing obesity pandemic, in diabetes, other factors. This will have significant effect on health care expenditure need for transplantation, which steatohepatitis already track overtake alcoholic as reason. characterized by ...

Non-alcoholic fatty liver disease (NAFLD) is becoming the most common chronic with many metabolic comorbidities, such as obesity, diabetes, and cardiovascular diseases. steatohepatitis (NASH), an advanced form of NAFLD, accompanies progression hepatic steatosis, inflammation, cell death, varying degree fibrosis. Interferons (IFNs) have been shown to play important roles in pathogenesis NAFLD NA...