BACKGROUND Consistently reported prognostic factors for glioblastoma (GBM) are age, extent of surgery, performance status, IDH1 mutational status, and MGMT promoter methylation status. We aimed to integrate biological and clinical prognostic factors into a nomogram intended to predict the survival time of an individual GBM patient treated with a standard regimen. In a previous study we showed t...

INTRODUCTION Existing nomograms predicting lymph node involvement (LNI) in prostate cancer (PCa) are based on conventional lymphadenectomy. The aim of the study was to develop the first nomogram for predicting LNI in PCa patients undergoing sentinel guided pelvic lymph node dissection (sPLND). MATERIALS AND METHODS Analysis was performed on 1,296 patients with PCa who underwent radioisotope g...

Attempting to curtail the growing epidemic of obesity is a daunting task. The American Academy of Pediatrics (AAP) obesity statement recommends early intervention.1 Prompt evaluation and treatment of early childhood obesity requires early recognition of an obese child or one who is at-risk for overweight with rapidly increasing body mass index (BMI).1 Childhood obesity is often underrecognized ...

Decades from now, when we fully understand the biologic basis for the clinical heterogeneity of prostate cancer, we will think of the current era as the Golden Age of Prostate Nomograms. Driven by the paucity of randomized data to guide treatment decisions, particularly in localized disease, nomograms have proliferated. Currently, there are more than 40 published prostate cancer nomograms to he...

Neuroendocrine tumors (NETs) are a heterogeneous group of cancers of which the commonest site is the small intestine (SI). Most information available to determine tumor behavior reflects univariate assessment of factors or is anecdotal or experience based. There currently exists no objective multivariate analysis of indices that defines SI NET prognosis. A key unmet need is the lack of a rigoro...

CONTEXT There is contention over whether reported dose correlates with toxicity in paracetamol poisoning and risk assessment is currently based on serum paracetamol concentration compared to a nomogram, irrespective of reported dose. Objective. To determine if reported dose predicts the need for N-acetylcysteine (NAC). METHODS Data were taken from paracetamol overdoses presenting to a tertiar...

OBJECTIVE To develop statistical prediction tools to select patients for short-stay thyroidectomy based on dynamic quantification of individual risk for postoperative hypocalcemia. DESIGN Clinical and biochemical factors that could influence postoperative calcium levels were analyzed. A multivariable logistic regression model was used to study the predictive ability of each variable for hypoc...

Background The prognosis of pancreatic carcinoma (PC) remains poor and the American Joint Committee on Cancer (AJCC) 8th staging system for survival prediction in PC patients after curative resection is still limited. Thus, the aim of this study is to refine a valuable prognostic model and novel staging system for PC with curative resection. Methods The data of 3,458 patients used in this stu...

STUDY OBJECTIVE To test the performance of a tool designed to estimate functional capacity in order to select a bicycle ramp protocol yielding a test duration from 8 to 12 min in healthy individuals, and to assess differences in exercise responses between bicycle and treadmill tests. PARTICIPANTS AND MEASURES Forty-one healthy and physically active volunteers (10 women; median age, 37 years; ...

Objective To configure and validate a novel prostate disease nomogram providing prostate biopsy outcome probabilities from a prospective study correlating clinical indicators and diagnostic parameters among Filipino adult male with elevated serum total prostate specific antigen (PSA) level. Methods All men with an elevated serum total PSA underwent initial prostate biopsy at our institution f...