An inverse nodal problem has first been studied for the Sturm-Liouville equation with one turning point. The asymptotic representation of the corresponding eigenfunctions of the eigenvalues has been investigated and an asymptotic of the nodal points is obtained. For this problem, we give a reconstruction formula for the potential function. Furthermore, numerical examples have been established a...

Prostate cancer is the second cause of cancer in males. The prophylactic pelvic irradiation is usually needed for treating prostate cancer patients with Subclinical Nodal Metestases. Currently, the physicians decide when to deliver pelvic irradiation in nodal negative patients mainly by using the Roach formula, which gives an approximate estimation of the risk of Subclinical Nodal Metestases. I...

The transcription factor Foxh1 mediates Nodal signaling. The role of Foxh1 in left-right (LR) patterning was examined with mutant mice that lack this protein in lateral plate mesoderm (LPM). The mutant mice failed to express Nodal, Lefty2 and Pitx2 on the left side during embryogenesis and exhibited right isomerism. Ectopic introduction of Nodal into right LPM, by transplantation of left LPM or...

The glycosylphosphatidylinositol (GPI)-anchored proteoglycan Cripto binds Nodal and its type I receptor Alk4 to activate Smad2,3 transcription factors, but a role during Nodal precursor processing has not been described. We show that Cripto also binds the proprotein convertases Furin and PACE4 and localizes Nodal processing at the cell surface. When coexpressed as in early embryonic cells, Crip...

COVID-19 is an infectious disease that has been declared a global public health emergency by the World Health Organization. Besides claiming over 3 million lives worldwide, led to unprecedented disruption in industrial productivity, trading, and food supply, resulting loss of livelihood. Despite initial success curbing spread diseases through lockdown rapid vaccine development, human are threat...