Cotranslational protein translocation is a universally conserved process for secretory and membrane protein biosynthesis. Nascent polypeptides emerging from a translating ribosome are either transported across or inserted into the membrane via the ribosome-bound Sec61 channel. Here, we report structures of a mammalian ribosome-Sec61 complex in both idle and translating states, determined to 3.4...

Flow shop scheduling of jobs has always been a popular problem that has found solutions in the number of heuristic and meta-heuristic techniques. In this manuscript, two-machine flow shop scheduling problem has been investigated while optimizing makespan and idle time of machines. Uncertainties in the processing time and set up times of jobs involved are also taken into consideration in the for...

This paper presents the findings of comparative research into labor, organizational and spatial practices a new kind hybrid civic spaces that we refer to as “social impact-driven repair shops.” These are an emerging typology urban dedicated repaired up-cycled items also go beyond functions traditional shop. Significantly, these shops run not purely for economic reasons, but rather position them...

INTRODUCTION There has been a surge in the number of vape shops in the USA. Research on the marketing practices of e-cigarette manufacturers is scarce and even less known are the practices of vape shop retailers. Past research on tobacco marketing has shown differences in the amount and content of marketing material, based on a community's demographic profile. This study examined marketing stra...

Many applications make use of hybrid programming models intermixing task and data parallelism in order to exploit modern architectures more eeciently. However, unbalanced computational load or idle times due to tasks that are blocked either in I/O or waiting on results from other tasks can cause signiicant performance problems. Fortunately, such idle times can be overlapped with useful computat...

This paper considers the single machine scheduling problem with linear earliness and quadratic tardiness costs. The research on the version with inserted idle time focused on an exact approach, while several heuristics had already been proposed for the version with no idle time. These heuristics were then the basis for the development of new heuristic procedures for the version with idle time. ...

In this paper we adopt the common cycle approach to economic lot scheduling problem and minimize the maximum aggregate inventory. We allow the occurrence of the idle times between any two consecutive products and consider limited capital for investment in inventory. We assume the setup times are negligible. To achieve the optimal investment in inventory we first find the idle times which minimi...