نتایج جستجو برای: nnos

تعداد نتایج: 2006  

Journal: :Human molecular genetics 2015
Stanley C Froehner Sarah M Reed Kendra N Anderson Paul L Huang Justin M Percival

Approaches targeting nitric oxide (NO) signaling show promise as therapies for Duchenne and Becker muscular dystrophies. However, the mechanisms by which NO benefits dystrophin-deficient muscle remain unclear, but may involve nNOSβ, a newly discovered enzymatic source of NO in skeletal muscle. Here we investigate the impact of dystrophin deficiency on nNOSβ and use mdx mice engineered to lack n...

Journal: :Acta biochimica Polonica 2013
Žilvinas Anusevičius Henrikas Nivinskas Jonas Šarlauskas Marie-Agnes Sari Jean-Luc Boucher Narimantas Čėnas

We examined the kinetics of single-electron reduction of a large number of structurally diverse quinones and nitroaromatic compounds, including a number of antitumour and antiparasitic drugs, and nitroaromatic explosives by recombinant rat neuronal nitric oxide synthase (nNOS, EC 1.14.13.39), aiming to characterize the role of nNOS in the oxidative stress-type cytotoxicity of the above compound...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2000
L Xue G Farrugia S M Miller C D Ferris S H Snyder J H Szurszewski

Nitric oxide (NO) and carbon monoxide (CO) seem to be neurotransmitters in the brain. The colocalization of their respective biosynthetic enzymes, neuronal NO synthase (nNOS) and heme oxygenase-2 (HO2), in enteric neurons and altered intestinal function in mice with genomic deletion of the enzymes (nNOS(Delta/Delta) and HO2(Delta/Delta)) suggest neurotransmitter roles for NO and CO in the enter...

2014
He Huang Huiying Li Sun Yang Georges Chreifi Pavel Martásek Linda J. Roman Frank L. Meyskens Thomas L. Poulos Richard B. Silverman

Selective inhibitors of neuronal nitric oxide synthase (nNOS) are regarded as valuable and powerful agents with therapeutic potential for the treatment of chronic neurodegenerative pathologies and human melanoma. Here, we describe a novel hybrid strategy that combines the pharmacokinetically promising thiophene-2-carboximidamide fragment and structural features of our previously reported potent...

Journal: :The Biological bulletin 2006
Mark D Hens Kenneth A Fowler Esther M Leise

Many marine organisms spend the early part of their lives as larvae suspended in the water column before metamorphosing into benthic reproductive adults. Metamorphosis does not occur until a larva has become competent to respond to appropriate stimuli and after a suitable habitat for the young juvenile has been encountered. The gaseous neurotransmitter nitric oxide is thought to be important in...

2016
Eduardo D. Costa Bruno A. Rezende Steyner F. Cortes Virginia S. Lemos

The family of nitric oxide synthases (NOS) has significant importance in various physiological mechanisms and is also involved in many pathological processes. Three NOS isoforms have been identified: neuronal NOS (nNOS or NOS 1), endothelial NOS (eNOS or NOS 3), and an inducible NOS (iNOS or NOS 2). Both nNOS and eNOS are constitutively expressed. Classically, eNOS is considered the main isofor...

Journal: :The Journal of clinical investigation 2000
C C Watkins A Sawa S Jaffrey S Blackshaw R K Barrow S H Snyder C D Ferris

Gastrointestinal dysfunction is common in diabetic patients. In genetic (nonobese diabetic) and toxin-elicited (streptozotocin) models of diabetes in mice, we demonstrate defects in gastric emptying and nonadrenergic, noncholinergic relaxation of pyloric muscle, which resemble defects in mice harboring a deletion of the neuronal nitric oxide synthase gene (nNOS). The diabetic mice manifest pron...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2002
Sergei A Korneev Ildiko Kemenes Volko Straub Kevin Staras Elena I Korneeva Gyorgy Kemenes Paul R Benjamin Michael O'Shea

We have used double-stranded RNA (dsRNA)-mediated RNA interference (RNAi) to disrupt neuronal nitric oxide (NO) synthase (nNOS) gene function in the snail Lymnaea stagnalis and have detected a specific behavioral phenotype. The injection of whole animals with synthetic dsRNA molecules targeted to the nNOS-encoding mRNA reduces feeding behavior in vivo and fictive feeding in vitro and interferes...

2014
Guanhong Xu Yue Chen Kun Shen Xiuzhen Wang Fei Li Yan He

Neuronal nitric oxide synthase (nNOS) plays an important role in neurotransmission and smooth muscle relaxation. Selective inhibition of nNOS over its other isozymes is highly desirable for the treatment of neurodegenerative diseases to avoid undesirable effects. In this study, we present a workflow for the identification and prioritization of compounds as potentially selective human nNOS inhib...

2012
Ludovic Tricoire Tania Vitalis

Nitric oxide (NO) is an important signaling molecule crucial for many physiological processes such as synaptic plasticity, vasomotricity, and inflammation. Neuronal nitric oxide synthase (nNOS) is the enzyme responsible for the synthesis of NO by neurons. In the juvenile and mature hippocampus and neocortex nNOS is primarily expressed by subpopulations of GABAergic interneurons. Over the past t...

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