نتایج جستجو برای: nitroimidazole

تعداد نتایج: 662  

Journal: :British medical journal 1971
B A Evans R D Catterall

A new substituted nitroimidazole, nitrimidazine (Naxogin), is compared with the established drug, metronidazole (Flagyl), for the treatment of vaginal trichomoniasis in a randomized double-blind trial. Nitrimidazine cured 39 (68%) out of 57 patients and showed no undesirable effects other than nausea in one patient. Metronidazole cured 51 (89%) out of 57 patients and also caused nausea in one p...

Journal: :Biochemical pharmacology 2003
Juan Diego Maya Soledad Bollo Luis J Nuñez-Vergara Juan A Squella Yolanda Repetto Antonio Morello Jacques Périé Gérard Chauvière

With the aim of determining the actual target(s) of nitro-group bearing compounds considered as possible leads for the development of drugs against Chagas' disease, we studied in parallel nitrofurans and nitroimidazoles. We investigated nine representative compounds for the following properties: efficacy on different Trypanosoma cruzi strains, redox cyclers, inhibition of respiration, productio...

Journal: :Molecules 2016
Cédric Spitz Fanny Mathias Alain Gamal Giuglio-Tonolo Thierry Terme Patrice Vanelle

We report here a practical and metal-free synthesis of novel enantiopure amides containing the drug-like 5-nitroimidazole scaffold. The first step was a metal-free diastereoselective addition of 4-(4-(chloromethyl)phenyl)-1,2-dimethyl-5-nitro-1H-imidazole to enantiomerically pure N-tert-butanesulfinimine. Then, the N-tert-butanesulfinyl-protected amine was easily deprotected under acidic condit...

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