JC2-6 15 February 2011 | ACP Journal Club | Volume 154 • Number 2 © 2011 American College of Physicians Review: Topical nitroglycerin reduces pain during ADL in patients with chronic tendinopathies Gambito ED, Gonzalez-Suarez CB, Oquinena TI, Agbayani RB. Evidence on the effectiveness of topical nitroglycerin in the treatment of tendinopathies: a systematic review and meta-analysis. Arch Phys M...

increase of calmodulin-dependent protein kinase II (CamKII) in rat spinal trigeminal nucleus after systemic nitroglycerin, Cephalalgia 27, 46-53. Cox-2 inhibitor attenuates NO-induced nNOS in rat caudal trigeminal nucleus, Selective inhibition of cyclooxygenase-2 attenuates nitroglycerin-induced calmodulin-dependent protein kinase II alpha in rat trigeminal nucleus caudalis, Neurosci Lett.

INTRODUCTION AND OBJECTIVES The magnitude of the change in heart rate during the first few minutes of the head-up tilt test has been used to predict the test's result. The aim of this study was to investigate whether the heart rate increase during the head-up tilt test potentiated with nitroglycerin is related to the development of syncope. PATIENTS AND METHOD The study included 158 consecuti...

OBJECTIVE To determine the efficacy of topical anti-ischemic drug therapy in the salvage of failing, random-pattern skin flaps. DESIGN Prospective, randomized, placebo-controlled, therapeutic trial. SETTING Academic medical center. SUBJECTS Sixty-one adult male Sprague-Dawley rats. INTERVENTION Each experimental rat underwent a caudally based random-pattern skin flap using the modified ...

Klassen, Christopher L., Jay H. Traverse, and Robert J. Bache. Nitroglycerin dilates coronary collateral vessels during exercise after blockade of endogenous NO production. Am. J. Physiol. 276 (Heart Circ. Physiol. 45): H918–H923, 1999.—In a previous study nitroglycerin failed to dilate coronary collateral vessels during exercise. This study tested the hypothesis that failure of nitroglycerin t...

Cardiac performance and mitral regurgitation were measured by Doppler echocardiography and right heart catheterization in 12 patients with severe congestive heart failure who performed isometric exercise during control and intravenous administration of dobutamine and nitroglycerin. During control isometric exercise, mitral regurgitant volume increased from 18±13 to 31±17 ml (p<0.01), while forw...

Cardiac performance and mitral regurgitation were measured by Doppler echocardiography and right heart catheterization in 12 patients with severe congestive heart failure who performed isometric exercise during control and intravenous administration of dobutamine and nitroglycerin. During control isometric exercise, mitral regurgitant volume increased from 18±13 to 31±17 ml (p<0.01), while forw...

The objective of the study was to estimate the contractility characteristics and electromechanical coupling of human internal thoracic artery (ITA) by mechanography and double sucrose gap technique to compare the effect of nitroglycerin with other pharmacological agents. The study of mechanical tension (mechanography) of the ITA segments has been performed in 14 patients undergone coronary arte...

Relaxation of rabbit and rat aorta by isoproterenol decreases with increasing age, whereas such responses caused by nitroglycerin or sodium nitrite are not age-dependent. In the present study, we sought to determine whether this relationship also exists in pulmonary arteries and portal veins. As was the case with the aorta, isoproterenol-induced relaxation of pulmonary arteries decreased as the...

BACKGROUND The basis for progressive attenuation of the effects of organic nitrates during long-term therapy (nitrate tolerance) remains controversial; proposed mechanisms include impaired nitrate bioconversion resulting in decreased release of nitric oxide (NO) from nitrates and/or increased NO clearance through a reaction with incrementally generated superoxide (O(2)(-)). METHODS AND RESULT...