نتایج جستجو برای: nitration
تعداد نتایج: 2143 فیلتر نتایج به سال:
Activation of the N-methyl-D-aspartate receptor (NMDAR) is fundamental in the development of hyperalgesia. Overactivation of this receptor releases superoxide and nitric oxide that, in turn, forms peroxynitrite (PN). All of these events have been linked to neurotoxicity. The receptors and enzymes involved in the handling of glutamate pathway--specifically NMDARs, glutamate transporter, and glut...
In the present study, we investigated how cytochrome c catalyzed the nitration of tyrosine at various pHs. The cytochrome c-catalyzed nitration of tyrosine occurred in proportion to the concentration of hydrogen peroxide, nitrite or cytochrome c. The cytochromec-catalyzed nitration of tyrosine was inhibited by catalase, sodium azide, cystein, and uric acid. These results show that the cytochrom...
Here we show that exogenous peroxynitrite results in nitration of phosphorylase as well inhibition glycogenolysis isolated intact mouse skeletal muscle during short-term repeated contractions. However, contractions the absence do not result or affect glycogenolysis, nor does addition antioxidants alter Thus is subject to redox control
Both β-amyloid (Aβ) peptides and oxidative stress conditions play key roles in Alzheimer’s disease. Hemin contributes to the development of disease as it possesses redox properties its level increases pathological or traumatic brain injuries. The aim this work was deepen investigation reactivity hemin–Aβ16 complex, considering ability catalyze oxidation nitration reactions. We performed kinetic...
In vivo, copper(II) is a major source of reactive oxygen species (ROS) via Fenton Haber Weiss reactions. Interest in Alzheimer’s disease has led to intensive studies into the generation of ROS catalyzed by copper(II) with or without the presence of β-amyloid (Aβ) peptides and biological antioxidants. We establish a potential connection between tyrosine nitration and copper(II) toxicity in neuro...
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