Groups of pregnant rats were injected with two successive daily doses of 3H-thymidine from gestational days 12 and 13 (E12 + 13) until the day before birth (E21 + 22). In radiographs from adult progeny of these rats the proportion of neurons generated on specific days was determined in the major nuclei of the upper medulla, with the exception of the vestibular and auditory nuclei. The neurons o...

Background: Tssk2, a member of the testis specific serine/threonine kinase (TSSK) family, is expressed predominantly in the testis and crucial for the formation and function of the sperm cells in mouse. Targeted deletion of Tssk1 and 2 in male chimeric mice caused infertility due to haploinsufficiency of the genes. Therefore it is reasonable to postulate that mutations in its human homologue TS...

In the presence of Mg2+, the EcoRV restriction endonuclease cleaves DNA specifically at the sequence GAT'ATC (where denotes the point of scission) [ I ] . Even the change of a single base pair within this sequence will lead to a million fold reduction of EcoRV activity [2]. Paradoxically, gel retardation experiments in the absence of Mg2+ show that, unlike EcoRl and many other type 11 restricti...

In an earlier paper (Y. Yamamura et al., Am. Rev. Respirat. Diseases 91:839, 1965; I. Azuma et al., Am. Rev. Respirat. Diseases, in press), we reported the isolation and purification of a polysaccharide from a culture filtrate of human tubercle bacilli Aoyama B strain. The polysaccharide was shown to have anaphylactic activity in guinea pigs which were sensitized by heatkilled tubercle bacilli....

We are writing to draw attention to an inconsistency in the amount of water in the packages of both white and grey MTA which are commercially available as ProRoot MTA Original (Dentsply International Inc., Johnson City, TN, USA) and ProRoot MTA (Dentsply International Inc.). In each package, there are five sachets (pouches) containing 1 g of ProRoot MTA powder and six ampoules of water. The man...

In this present investigation, the effect and optimization of machining parameters on the kerf width and surface roughness in wire electrical discharge machining (WEDM) operations of Al 60661 hybrid composite was studied. The hybrid metal matrix composite was fabricated by stir casting process using particulates SiC and graphite each in Al6061 alloy. The experiments were designed with L27 ortho...

In the present work, we studied the pharmacokinetics and metabolic disposition of [G-H]paclitaxel in a female patient with recurrent ovarian cancer and severe renal impairment (creatinine clearance: ;20 ml/min) due to chronic hypertension and prior cisplatin treatment. During six 3-weekly courses of paclitaxel at a dose level of 157.5 mg/m (viz. a 10% dose reduction), the renal function remaine...

Clinical use of the nonsteroidal anti-inflammatory drug diclofenac (DF) is associated with an incidence of idiosyncratic hepatoxicity. The formation of reactive metabolites of DF in vivo has been proposed to be responsible for such toxicity. One type of reactive metabolite, a benzoquinone imine of DF formed through oxidation by cytochromes P450, can be trapped by glutathione in vitro in liver m...