The concept of pharmacological efficacy has been much discussed recently with significant interest both in inverse agonists and in protean agonists (i.e., compounds with functional selectivity for different effector responses). Although first proposed in the mid-1990s, the pharmacological and therapeutic importance of these concepts is now receiving wider support. Two articles in recent issues ...

A collection of Paguroidea recently obtained during deep-water expeditions along the coast of Brazil, forms the basis of this report. Of the 14 species reported from Brazil, 11 represent range extensions to the south, and one, Michelopagurus atlanticus (Bouvier, 1922), is a first record for the western Atlantic. The specimens were compared with types and western Atlantic materials deposited in ...

A recommendation of: Christelle Fraïsse, Alan Le Moan, Camille Roux, Guillaume Dubois, Claire Daguin-Thiébaut, Pierre-Alexandre Gagnaire, Frédérique Viard, Nicolas Bierne Introgression between highly divergent sea squirt genomes: an adaptive breakthrough? https://doi.org/10.1101/2022.03.22.485319

The central limit theorem states that the sample mean X̄ follows approximately the normal distribution with mean μ and standard deviation σ √ n , where μ and σ are the mean and standard deviation of the population from where the sample was selected. The sample size n has to be large (usually n ≥ 30) if the population from where the sample is taken is nonnormal. If the population follows the norm...

We give a complete numerical description of the geometry of the four-point contact interaction of closed bosonic string field theory. Namely, we compute the boundary of the relevant region of the moduli space of the four-punctured spheres, and everywhere in this region we give the local coordinates around each punctures in terms of a Strebel quadratic differential and mapping radii. The numeric...

Four researchers — Nicolas Bonne, Cheryl Fogle-Hatch, Garry Foran and Enrique Perez Montero discuss the accessibility challenges in astronomy research, education outreach for persons who are blind or visually impaired. Solutions to these create innovative data analysis methods all astronomers.

In diesem Kommentar zum Debattenaufschlag von Yannick Ecker, Tatiana López und Nicolas Schlitz möchte ich Skepsis an der den Autor:innen diagnostizierten „zunehmenden Verbindung betrieblichen städtischen Konflikten“ äußern daran anschließend Vorschlag machen, in geforderten „Auseinandersetzung mit Arbeit kritischen Stadtforschung“ (auch) eine globale Perspektive einzunehmen.