نتایج جستجو برای: nfat5

تعداد نتایج: 312  

Journal: :Molecular cell 2010
Carmit Levy Mehdi Khaled Dimitrios Iliopoulos Maja M Janas Steffen Schubert Sophie Pinner Po-Hao Chen Shuqiang Li Anne L Fletcher Satoru Yokoyama Kenneth L Scott Levi A Garraway Jun S Song Scott R Granter Shannon J Turley David E Fisher Carl D Novina

When it escapes early detection, malignant melanoma becomes a highly lethal and treatment-refractory cancer. Melastatin is greatly downregulated in metastatic melanomas and is widely believed to function as a melanoma tumor suppressor. Here we report that tumor suppressive activity is not mediated by melastatin but instead by a microRNA (miR-211) hosted within an intron of melastatin. Increasin...

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