The focus was to investigate the anatomical specifics of v. portae, vv. hepaticae and ductus choledochus by corrosion. We investigated 10 sexually mature, clinically healthy New Zealand White rabbits, 8 months old, weighing 2.8 kg 3.2 kg. To determine veins bile vessels, a cold-curing acrylic-based plastic (Duracryl +) used. main portal vessel an intraorganic continuation after its branching in...

pmmSe. The conversion of L-arginine into L-citrulline by nitric oxide synthase (NOS) leads to nitric oxide formation. Two major NOS isoforms exist, a &*-dependent NOS (cNOS) and a &“-independent NOS (iNOS). The cNOS is constitutive of many cells while the iNOS is not expressed in normal conditions but only induced after the stimulation by different factors (endotoxins, cytokines, etc...). This ...

The New Zealand white (NZW) rabbit fed a 0.1% cholesterol-enriched diet (CD) typically responds (normoresponsive, NR) by quickly developing hypercholesterolemia. To study the underlying mechanisms responsible for the widespread phenomenon of inter-individual variability of response to dietary cholesterol, a unique hypercholesterolemia-resistant (RT) rabbit model was developed. These animals wer...

The New Zealand Black (NZB) Lbw2 locus (lupus NZB x New Zealand White (NZW) 2 locus) was previously linked to mortality and glomerulonephritis, but not to IgG autoantibodies, suggesting that it played a role in a later disease stage. To define its contribution, (NZB x NZW)F1 hybrids (BWF1) containing two, one, or no copies of this locus were generated. Lack of the NZB Lbw2 indeed reduced mortal...

The anti-RNA antibodies were present in consanguineous household contacts but not in nonconsanguineous household contacts. These findings strengthen the hypothesis that both an environmental agent, possibly a virus, as well as the genetic response are important in the pathogenesis of SLE. Family members may therefore be a logical population in whom to search for specific antibodies to a viral a...

The purpose of the work presented here was to investigate endotheliumdependent relaxations in the rabbit coronary ligation model of heart failure. We investigated endothelium-dependent relaxations at the level of larger vessels (thoracic aorta and vena cava left renal artery and left renal vein lateral saphenous artery and lateral saphenous vein and finally central ear artery and marginal e...

The goal of this work was to develop and validate a pancreas tumor animal model to investigate the relationship between photodynamic therapy (PDT) effectiveness and photosensitizer drug delivery. More specifically, this work lays the foundation for investigating the utility of dynamic contrast enhanced blood perfusion imaging to be used to inform subsequent PDT. A VX2 carcinoma rabbit cell line...

The present study was designed to evaluate the effects of platelet growth factors and periosteal mesenchymal stem cells on bone healing process, radiographically. Forty male White New Zealand rabbits in five equal groups were used in this study. A 2 mm full thickness bone defect was made in left radial bone of each animal. In group A (control) the defect was left with no medical intervention. I...