Aspergillus galactomannan antigenemia is an accepted tool for the diagnosis of invasive pulmonary aspergillosis (IPA) in neutropenic patients. Little known, however, about utility this biomarker to assess efficacy antifungal therapies. The pharmacokinetics (PK) and pharmacodynamics (PD) posaconazole treatment prophylaxis were investigated persistently rabbit model fumigatus IPA at doses between...

(1990). Lingual cellulitis causing upper airways obstruction in neutropenic patients. BMJ (Clinical research ed.), 300(6716):24.

Intensive chemotherapy/radiotherapy in cancer, especially with hematologic malignancies, causes cellular injury and suppression of inflammatory responses, which increase the risks neutropenia febrile episodes. Absolute neutrophil count < 1 ? 109/L is considered neutropenia, absolute 0.5 or that expected to decrease next 48 hours severe while 0.1 109 referred as profound neutropenia. Febrile ...

We observed 71 febrile, neutropenic episodes in 25 oncohematological patients after chemotherapy during a 3-years period from 1995 to 1997. Three patients died because of infections (pneumonia with septic shock, gram-negative bacteremia and sepsis, pseudomembranous colitis and diffuse peritonitis) at the period of prolonged, deep neutropenia (absolute neutrophil count < 100/mm3). During the 71 ...

Background. Neutropenic enterocolitis is one of the most common gastrointestinal complications seen in patients who are receiving chemotherapy for leukemia. Severe neutropenia is the main underlying factor of this pathology. It is characterized by fever and abdominal pain. Case Presentation. Herein, we report a case of neutropenic enterocolitis which presented with intestinal perforation in an ...