N ontuberculous mycobacteria rarely cause keratitis. Most reported cases have been described in compromised corneas (ie, after penetrating keratoplasty, refractive surgery, and contact lens wear). The most frequently recovered nontuberculous mycobacteria are the rapid growers, Mycobacterium fortuitum and Mycobacterium chelonae. Occasional cases of keratitis caused by the slower-growing Mycobact...

Bacterial keratitis is a disease of the cornea characterized by pain, redness, inflammation, and opacity. Common causes of this disease are Pseudomonas aeruginosa and Staphylococcus aureus. Animal models of keratitis have been used to elucidate both the bacterial factors and the host inflammatory response involved in the disease. Reviewed herein are animal models of bacterial keratitis and some...

It is well known that lesions affecting the trigeminal nerve may lead to the development ofneurotrophic keratitis (Magendie, I 824), but the incidence and the extent of the keratitis seen by biomicroscopic examination of the cornea, and in particular its effect upon visual acuity, are not well documented. The present study was undertaken to investigate these aspects of keratitis, in corneae ren...

Three patients, women aged 69, 25 and 30 years, with refractory keratitis were found to have a rare infection with Acanthamoeba. All wore soft contact lenses. The frequency of Acanthamoeba keratitis increased in recent years. At present, an efficacious antiprotozoal therapy is available, for instance in the form of polyhexamethylene biguanide and propamidine. In cases of refractory keratitis, t...

PURPOSE The purpose of this study is to describe the ineffectiveness of intrastromal voriconazole injection for filamentous fungal keratitis by contrasting the effectiveness for yeast keratitis. METHODS We examined seven fungal keratitis patients prospectively. All yeast was identified by molecular phylogenetic analyses of the chromosomal regions coding for the D1/D2 domain of the large-subun...

BACKGROUND Mycotic keratitis is an important cause of corneal blindness world over including India. Geographical location and climate are known to influence the profile of fungal diseases. While there are several reports on mycotic keratitis from southern India, comprehensive clinico-microbiological reports from eastern India are few. The reported prevalence of mycotic keratitis are 36.7%,36.3%...

THE concept of an association between congenital syphilitic interstitial keratitis and the development of late glaucoma is not new. Hutchinson (1863) reported the case of a man aged 24 with congenital syphilis who had suffered bilateral interstitial keratitis at the age of 6; both eyes had deeply cupped and atrophic optic discs and iridectomy failed to control the glaucoma. Hutchinson believed ...

Scanning electron microscopy of the endothelium of experimental disciform keratitis revealed corneal endothelial changes which distinguished disciform oedema from the more progressive stages of disciform keratitis. The endothelium of corneas with disciform oedema were wholly intact and characterised by subtle morphological alterations. In contrast, the more progressive stages of disciform kerat...

Photodynamic inactivation of virus was tested as a potential therapeutic tool for herpesvirus-induced keratitis, which is a leading cause of blindness and disability. Experimental keratitis produced in rabbits by infection with herpesvirus isolated from a human periorbital lesion was treated with proflavine and light. The herpetic keratitis could be rapidly resolved by the dye-light treatment, ...

We aim to highlight the key factors for a good outcome of fungal keratitis. We describe a case of contact lens-related Fusarium keratitis in a young girl. After identification of Fusarium spp under direct microscopic examination and in culture, a prolonged treatment with topic natamycin 5% was started and administered for five months with restitutio ad integrum of the eye. Prompt microbiologica...