Experiments carried out in our laboratory in the last 20 years show that the blood-brain barrier plays a crucial role in neuroprotection and neuroregeneration [1,2]. Using various animal models of traumatic brain and spinal cord injuries in rats and mice, we found that the blood-brain and the blood-spinal cord barriers became leaky to various sized tracers ranging from 12 Å (Lanthanum ion) to 8...

Objective To track the interplay between (micro-) structural changes along trajectories of nociceptive pathways and its relation to presence intensity neuropathic pain (NP) after spinal cord injury (SCI). Methods A quantitative neuroimaging approach employing a multiparametric mapping protocol was used, providing indirect measures myelination (via contrasts such as magnetisation transfer (MT) s...

Multiple sclerosis (MS) is a chronic autoimmune central nervous system (CNS) disease characterized by inflammation, demyelination and axonal damage. The most important goal in MS treatment to provide neuroregeneration. However, current treatments only work slow the progression of MS. Ocrelizumab humanized anti-CD20 monoclonal antibody used In this study, it was aimed investigate effects on prol...

PERSPECTIVE Genetically modified human umbilical cord blood cells as a promising strategy for treatment of spinal cord injury Spinal cord injury (SCI) continues to be a pressing health and social problem. The injury leads to neuronal and glial cell death accompanied by degeneration of nerve fibers. There are currently no particularly effective treatments. SCI causes profound disability of peopl...

Abstract The facial nerve is the main motor that activates mimic musculature of face. Nerve tree injuries lead to paralysis same half In addition functional damage in form difficulty chewing, speaking and closing eyes, paresis cause pronounced emotional social problems patients. etiology diverse, including trauma, neurological, infectious, metabolic, vascular, neoplastic processes, as well idio...

INTRODUCTION Human neurodegenerative diseases increase progressively with age and present a high social and economic burden. Growth hormone (GH) and insulin-like growth factor-1 (IGF-1) are both growth factors exerting trophic effects on neuronal regeneration in the central nervous system (CNS) and peripheral nervous system (PNS). GH and IGF-1 stimulate protein synthesis in neurons, glia, oligo...