Peter S. McPherson,* Young-Kee Kim,† Hector Valdivia,† C. Michael Knudson,‡ Hiroaki Takekura,§ Clara Franzini-Armstrong,§ Roberto Coronado,† and Kevin P. Campbell*‡|| *Program in Neuroscience ‡Department of Physiology and Biophysics || Howard Hughes Medical Institute University of Iowa College of Medicine Iowa City, Iowa 52242 †Department of Physiology University of Wisconsin Medical School Mad...

Editorial Neuron Reports bers of our Board of Associate Editors. We are looking If you flip back a few pages to the Table of Contents, you will notice something new. A new article format forward to continuing to work with the entire Editorial called a " Report. " In this particular case it is an article Board to ensure that Neuron brings you the best and by Saal et al. from Rob Malenka's lab de...

(1) Signal Detection Theory: Consider the two-alternative-choice motion discrimination task in which the subject has to determine the direction of motion of a stimulus. As ideal observers, we obtain access to two neurons with opposite tuning (so that e.g. neuron 1 will fire more strongly than neuron 2 if the motion stimulus moved leftwards, and neuron 2 more strongly than neuron 1 if the motion...

The specification of spinal interneuron and motor neuron identities initiates within progenitor cells, while motor neuron subtype diversification is regulated by hierarchical transcriptional programs implemented postmitotically. Here we find that mice lacking GDE2, a six-transmembrane protein that triggers motor neuron generation, exhibit selective losses of distinct motor neuron subtypes, spec...

In-situ observations of subsurface ocean temperatures are, in many regions, inconsistently distributed time and space. These spatio-temporal inconsistencies the observational network lead to difficulties utilizing those effectively for model evaluation or understanding larger-scale characteristics. Model accuracy characteristics is especially important within regions that contain complex struct...

We consider a wide class of spiking neuron models, defined by rather general set of conditions typical for basic models like leaky integrate and fire, or binding neuron model. A neuron is fed with a point renewal process. A relation between the three probability density functions (pdf): (i) pdf of input interspike intervals, (ii) pdf of output interspike intervals of a neuron with instantaneous...

This directory contains the Neuron code for the CA1 pyramidal cell model and the experiments described in: 1. Poirazi, P. Brannon, T. & Mel, B.W. Arithmetic of Subthreshold Synaptic Summation in a Model CA1 Pyramidal Cell. In Press, Neuron , February 2003. 2. Poirazi, P. Brannon, T. & Mel, B.W. Online Supplement: About the Model. In Press, Neuron , February 2003. 3. Poirazi, P. Brannon, T. & Me...

The uptake of guanethidine (3.3×10-5 M), debrisoquin (8.4×10-4 M), bretyliun (5.0 10-4 M) and xylocholine (1.0×10-3 M) by adrenergic neuron was studied indirectly by testing the ability of noradrenaline (NA) regarding low temp. or sodium deprivation to prevent or reverse adrenergic neuron blocking action in the indirectly stimulated ...

Background: B cell CLL/lymphoma 2 protein, bcl-2, is an important anti-apoptotic factor that has been implicated in lithium’s neuroprotective effect. However, most studies have focused on assessing the effects of lithium in neurons, ignoring examination of bcl-2 in astrocytes, which also influence neuronal survival and are affected in bipolar disorder. The aim of this study was to evaluate whet...

Background Endometriosis is a common gynecological disease, can cause severe pelvic pain. Studies demonstrated the presence of sensory nerve fibers in endometrium of endometriosis patient. Nevertheless, no information is available on mechanisms of sensory nerve formation in eutopic or ectopic lesions. Since HOX genes have important roles in both reproductive tract and nerve growth, we decided t...