The aim of the present study was to uncover the mechanism underlying the neuroprotection of Hemin‑mediated neuroglobin (Ngb) in an in vivo model of brain injury. Sixty healthy male Sprague-Dawley rats were randomly divided into 5 groups (n=12, each group): sham surgery, ischemia, Hemin, LY294002 (LY) and Hemin + LY. Focal cerebral ischemia was established by unilateral middle cerebral artery oc...

Posterior reversible encephalopathy syndrome (PRES) is a clinical and radiological syndrome, characterized by acute onset of headache, altered mental status, visual impairment, nausea, vomiting, seizure, hypertension. PRES condition if it recognized early, but neurological damage or even death may occur. Herein, we present two cases ALL who developed during their induction therapy literature re...

INTRODUCTION Admission to the intensive care unit (ICU) may be preceded by dramatic events leading to permanent neurological injury. Plasma S100 protein levels are proved to be clinically useful in predicting neurological outcome following cardiac arrest. It is unclear, however, whether this may be extrapolated to a broader population of ICU patients. AIM To assess the utility of plasma S100 ...

many patients fear about neurological disorders because of mistrust to their judgments. reality is that neurological system is one of the simplest systems, but unfortunately we discuss about it in a form that induce fear to people. suppose that an old person hospitalized for cerebro-vascular accident (cva) and increased intracranial pressure (icp). results of your assessment can increase patien...

clinical neurology has been traditionally considered as an academic speciality in which the specialist regurgitates his/her knowledge of neurology without being able to do much for the patient. this attitude is no longer acceptable. surge of information and discoveries in neurosciences within the last two decades translated into therapeutic interventions which is literally life saving in some o...

The highly conserved abundant nuclear protein poly (ADP-ribose) polymerase-1 (PARP-1) is activated by DNA damage. PARP-1 activation is associated in DNA repair, cell death and inflammation. Since oxidative stress induced robust DNA damage and wide spread inflammatory responses are common pathologies of various CNS diseases, the attention towards PARP-1 as a therapeutic target has been amplifyin...

BACKGROUND Wilson disease is a rare genetic disorder in which impaired copper excretion results in toxic copper levels and tissue damage. Manifestations are primarily hepatic and/or neuropsychiatric, with a variety of neurological phenotypes. The aim of this study was to characterize neurological signs of Wilson disease in newly diagnosed patients and to determine whether they correlated with d...

Background: Fixed and dilated pupils (FDPs) have become synonymous with devastating neurological damage brainstem injury commonly associated mass effect herniation. Infrequently, changes in pupillary light response been described seizures; however, the loss of documented Neurological Pupil index has not well established patients seizures.Case Report: We present a case report describing middle-a...

Thoracolumbar spine trauma typically occurs when high-energy forces damage bony and ligamentous spinal structures and, in severe cases, the spinal cord. These injuries often cause considerable neurological deficits as a result of the damage. Computed tomography (CT) is the imaging method of choice for determining injury severity in most victims of multiple trauma. In addition to describing vari...

Twenty patients with a traumatic third nerve palsy had sustained a closed head injury with prolonged loss of consciousness in a high-speed deceleration accident. Sixteen were male, and the average age was 25 years. Seven had skull or facial fractures, 15 damage to the anterior visual pathways, and 16 other permanent neurological damage. Nineteen developed the misdirection/regeneration syndrome....