Bronchopulmonary neuroendocrine tumors (BPNETs) are the second most common subset of NETs after gastroenteropancreatic NETs. Historically, clinical studies have excluded BPNETs during drug development and data is often extrapolated from non-BPNETs. However, growing burden novel treatment strategies including targeted therapies radiopharmaceuticals paved way for revisiting strategies. In this re...

Secondary and primar neoplasms of the appendix are rare tumors found in approximately 1% appendectomy specimens, with epithelial neuroendocrine being more frequent. (1). Epithelial adenocarcinoma is most common malignancy mucinous (37%) non-mucinous (27%) histological subtypes. We present a clinical case.

Neuroendocrine tumors (NETs) originate in the neuroendocrine cells of the neural crest (Kulchitsky cells). If neuroendocrine tumors arising in the digestive tract or lung may occasionally result in skin metastases, primary soft tissue or skin NETs are infrequent. The current paper presents the case of an elderly woman patient with neuroendocrine tumors arising de novo in the left upper thigh, a...

Neuroendocrine tumors are unique and rare tumors originating from neuroendocrine cells. Large cell neuroendocrine tumors have been found in almost every organ such as gastrointestinal tract, bronchopulmonary, pancreas, uterine cervix, urinary bladder and salivary gland, but primary sites in gastrointestinal tract and lung are the most frequent. These neoplasms show neuroendocrine differentiatio...

To the Editor, Mixed endocrine glandular tumors of the gastrointestinal tract are rare lesions. In these tumors, the glandular and neuroendocrine components display a broad spectrum of combinations with marked variability in histopathology, immunohistochemical properties and clinical prognosis. We hereby report two cases of colonic tubulovillous adenomas, concomitantly containing a neuroendocri...

The systematic application of immunohistochemical techniques to the study of tumors has led to the recognition that neuroendocrine cells occur rather frequently in exocrine neoplasms of the gut. It is now well known that there is a wide spectrum of combinations of exocrine and neuroendocrine components, ranging from adenomas or carcinomas with interspersed neuroendocrine cells at one extreme to...

Nurse developments in the management of neuroendocrine tumours have changed significantly over the past three years. At the Royal Free Hospital we set up the nurse specialist role due to the expansion of patients being referred to the specialist unit, and the obvious need for a nursing input into their care. The nurse specialist can make a significant contribution within the context of a multid...