There is an urgent need to develop predictive methodologies that will fast-track the industrial implementation of organic solvent nanofiltration (OSN). However, performance prediction OSN membranes has been a daunting and challenging task, due high number possible solvents complex relationship between solvent-membrane, solute-solvent, solute-membrane interactions. Therefore, instead developing ...

In this paper we describe a microcomputer program (HTP) for predicting the location and orientation of alpha-helical transmembrane segments in integral membrane proteins. HTP is a neural network-based tool which gives as output the protein membrane topology based on the statistical propensity of residues to be located in external and internal loops. This method, which uses single protein sequen...