BACKGROUND Breakdown of renal endothelial, tubular and glomerular matrix collagen plays a major role in acute kidney injury (AKI) development. Such collagen breakdown releases endostatin into the circulation. The aim of this study was to compare the AKI predictive value of plasma endostatin with two previously suggested biomarkers of AKI, cystatin C and neutrophil gelatinase-associated lipocali...

PURPOSE The aim of the present study was to develop an osteoporosis risk-assessment model to identify high-risk individuals among Korean men. MATERIALS AND METHODS The study used data from 1340 and 1110 men ≥50 years who participated in the 2009 and 2010 Korean National Health and Nutrition Examination Survey, respectively, for development and validation of an osteoporosis risk-assessment mod...

A promising hypertension risk prediction score using data from the US Framingham Offspring Study has been developed, but this score has not been tested in other cohorts. We examined the predictive performance of the Framingham hypertension risk score in a European population, the Whitehall II Study. Participants were 6704 London-based civil servants aged 35 to 68 years, 31% women, free from pre...

BACKGROUND The American Heart Association has established criteria for the evaluation of novel markers of cardiovascular risk. In accordance with these criteria, we assessed the association between a multi-locus genetic risk score (GRS) and incident coronary heart disease (CHD), and evaluated whether this GRS improves the predictive capacity of the Framingham risk function. METHODS AND RESULT...

A promising hypertension risk prediction score using data from the US Framingham Offspring Study has been developed, but this score has not been tested in other cohorts. We examined the predictive performance of the Framingham hypertension risk score in a European population, the Whitehall II Study. Participants were 6704 London-based civil servants aged 35 to 68 years, 31% women, free from pre...

Background: The node classification outlined in the seventh edition of the tumor-node-metastasis (TNM) classification is based solely on the number of metastasized lymph nodes. We examined the prognostic value of apical lymph node metastasis and the additive value of incorporating apical lymph node status into a risk model based on the seventh edition. Methods: Our cohort study involved 1355 pa...

Von Willebrand factor (vWF) is a biomarker of endothelial dysfunction. We investigated its role on prognosis in anticoagulated atrial fibrillation (AF) patients and determined whether its addition to clinical risk stratification schemes improved event-risk prediction. Consecutive outpatients with non-valvular AF were recruited and rates of thrombotic/cardiovascular events, major bleeding and mo...

BACKGROUND Biomarkers may contribute to risk stratification in coronary heart disease (CHD). We examined whether plasma midregional proadrenomedullin (MR-proADM) concentration at baseline and its change over one year predicts long-term outcomes in stable CHD patients. METHODS The LIPID study randomised patients 3-36 months after an acute coronary syndrome with total cholesterol 4.0-7.0 mmol/L...

BACKGROUND We prospectively evaluated the incremental prognostic value of transient ischemic dilation (TID) in patients with type 2 diabetes mellitus during long-term follow-up and estimated cardiac death and nonfatal myocardial infarction (MI) using traditional approaches of prognostication to more recent methods. METHODS AND RESULTS A total of 672 consecutive diabetic patients with availabl...

To the Editor: The results from the VAMPAHICA Study Group presented in the article “Usefulness of Optic Fundus Examination With Retinography in Initial Evaluation of Hypertensive Patients.” provide evidence that the use of retinography would increase the proportion of people classified as being at high risk of developing a major cardiovascular event within ten years.1 However, the study does no...