A patient presenting an unusual clinical picture was recently admitted to the New Haven Hospital. She showed definite objective evidence of involvement of the central nervous system, but other obscure signs present made an accurate diagnosis difficult. At necropsy a most unexpected lesion was found involving the base of the brain, the nerve roots, and the spinal cord. The case is of particular ...

Four patients are described in whom a follicular carcinoma developed following thyroidectomy for a benign follicular neoplasm. It is possible that the initial thyroid neoplasm was a well- differentiated follicular carcinoma which was microscopically indistinguishable from a benign adenoma. Realizing this pathologic pitfall in thyroid diagnosis, the need for meticulous examination of the pa...

Graphical abstract Abstract The phenomenal extracellular matrix (ECM) remodelling of the cervix that precedes myometrial contraction labour at term or preterm appears to share some common mechanisms with occurrence, growth, invasion and metastasis cervical carcinoma. Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases pivotal complex tissue modulation includes degradation, exchan...

Urothelial bladder cancer (UBC) is the most common urinary neoplasm in China. CCN family protein 2 (CCN2), a cysteine-rich matricellular protein, is abnormally expressed in several cancer types and involved in tumor progression or chemo-resistance. However, detailed expression patterns and effects of CCN2 in UBC still remain unknown. We found that down-regulation of CCN2 suppressed proliferatio...

Few cases of equine mast cell tumour have been reported in the literature. Most describe solitary nodular lesions of the skin and subcutaneous tissue that occasionally involve the underlying musculature (Altera and Clark 1970; Doran and Collins 1986; Nyrop et al. 1986; McEntee 1991). Lesions are generally confined to soft tissues and appear to be hyperplastic rather than neoplastic. One case in...

Hematogenous metastasis to skeletal muscle from urothelial carcinoma is extremely rare and metastatic disease to skeletal muscle tends to be found in people with advanced-stage neoplasm. We report in this paper a case of left sartorius muscle metastasis from urothelial cell carcinoma. A left nephroureterectomy with bladder cuff excision was performed and revealed a high-grade papillary transiti...

In recent papers (1, 5) it was suggested that invasion of the adjacent normal tissues by malignant tumors may be facilitated by the presence of a spreading fac,tor such as hyaluronidase. In support of this hypothesis, it was reported that some human carcinomas have been found to contain a sprcading factor. Further support would bc given to this hypothesis if it could be shown that invasiveness ...