A seizure is defined clinically as paroxysmal alternations in neurological function, namely, motor, behavioral, or autonomic function. Neonatal seizures tend to be brief, because immature neurons cannot sustain repetitive activity for a long time and tend to be focal or multifocal. Neonatal seizures are common: estimates of the incidence of clinical seizures in term infants range from 0.7-2.7 p...

how to cite this article: islami z, ataee nakhaei mh. neurological manifestations of an old disease: a case report. iran j child neurol. 2013 summer; 7(3): 55-57.   objective neurological manifestations of neonatal disorders have various causes, among them neonatal tetanus, albeit rare, is a potentially fatal and preventable disease, which is seen in underdeveloped and developing countries. alt...

Background: M-CSF is a cytokine mediating the growth, proliferation and differentiation of various cell types including macrophages, trophoblast cells, and osteoclasts. It plays an important role in immunity reproduction, follicle development and ovulation. In the present study, we describe the important role of the changes in serum M-CSF levels during the menstrual cycle, in the process of fol...

Alloimmunization to granulocyte-specific antigens can occur during pregnancy. Maternal antibodies of IgG class can cross the placenta to result in alloimmune neonatal neutropenia. Antibodies to human neutrophil antigens anti-HNA-1a, HNA-1b, and HNA-2a have been most commonly reported to cause alloimmune neonatal neutropenia. Isoantibodies to Fc gamma RIIIb (CD16) if mother is a HNA-null phenoty...

Neonatal Herpes simplex virus (HSV) infection is usually caused by type 2 virus following maternal peripartum genital HSV infection. Type 1 HSV usually affects infants after 3 months of age. Neonatal HSV infection present as skin, eye and mouth disease (SEM disease); affect the central nervous system (CNS disease) or involve multiple organs (Disseminated disease). Illustrative case: A full term...

Background: There are many reports regarding to effects of Granulocyte colony-stimulating factor (G-CSF) and stem cell factor (SCF)alone in liver repair .But conflicting data have been reported regarding the role of growth factors such as G-CSF and SCF in the liver regeneration system. Also, there is not such data regarding to effects of co-administration both of G-CSF and SCF in the liver dama...

The human granulocyte-macrophage colony stimulation factor (hGM-CSF) gene was cloned in the pET 23a( +) expression vector under the control of strong bacteriophage T7 transcription and translation signals. The hGM-CSF gene was transferred into E. coli strainBL21 (DE3)pLysS andIPTG was used for induction of GM-CSF gene. Production of the target protein was obtained as revealed by ELISA and ...

introduction: in iran, thousands of young individuals become victims of head injury annually. head injury can damage neuronal cells which may in turn complicate the recovery of the patients. also, the increase of iron in cerebrospinal fluid (csf) following head injury may contribute to the hypoxic-ischemia brain damage by catalyzing the formation of free radicals (harber-weiss rection). the obj...