Objectives: Against the background of evidence-based treatments for schizophrenia resistant to medication, the implementation of cognitive-Rehabilitation therapy (CRT) becomes more important, especially about patients who don’t response to medication. There is less evidence for group format and face to face structure of CRT and also for resistant to medication patients. This research investigat...

Aim: The aim of this study is to evaluate the effect of memantine on negative symptoms in patients with schizophrenia and schizoaffective. Methods: This is a double- blind randomized clinical trial. 58 patients participated in the study, 29 patients were randomly assigned to the memantine group and 29 patients to the placebo group. For assessing negative signs, and we used scale for the assess...

Aim: The aim of this study is to evaluate the effect of memantine on negative symptoms in patients with schizophrenia and schizoaffective. Methods: This is a double- blind randomized clinical trial. 58 patients participated in the study, 29 patients were randomly assigned to the memantine group and 29 patients to the placebo group. For assessing negative signs, and we used scale for the assess...

Abstract Background: Many schizophrenic patients are engaged in self-medication drug abuse, including narcotics. It is assumed that many of these patients have a greater number of psychotic symptoms, and show noncompliance with treatment. In this study, we investigated relationship of positive and negative symptoms and opioid dependence in these patients. Methods: This was a descriptive...