Renewable energy (RE) generation levels are increasing in modern power systems at a fast rate due to their advantages of clean and non-exhaustible nature energy. However, this type creates technical challenges terms operation control uncertain un-predictable generation. Islanding is an operational scenario where there loss grid RE generators continue feed the local load. This has harmful effect...

BACKGROUND AND PURPOSE The inflammatory response is a critical component of ischemic stroke. In addition to its physiological role, the mechanisms behind transendothelial recruitment of immune cells also offer a unique therapeutic opportunity for translational stem cell therapies. Recent reports have demonstrated homing of neural stem cells (NSC) into the injured brain areas after intravascular...

Tumor-initiating cells are a subpopulation in aggressive cancers that exhibit traits shared with stem cells, including the ability to self-renew and differentiate, commonly referred to as stemness. In addition, such cells are resistant to chemo- and radiation therapy posing a therapeutic challenge. To uncover stemness-associated functions in glioma-initiating cells (GICs), transcriptome profile...

The orphan nuclear receptor TLX, also known as NR2E1, is an essential regulator of neural stem cell (NSC) self-renewal, maintenance, and neurogenesis. In vertebrates, TLX is specifically localized to the neurogenic regions of the forebrain and retina throughout development and adulthood. TLX regulates the expression of genes involved in multiple pathways, such as the cell cycle, DNA replication...

We propose a modular multilevel converter (MMC) based three-phase four-wire (3P4W) split capacitor distribution static synchronous compensator (DSTATCOM), aiming at compensating unbalanced and reactive load currents. Due to the zero-sequence current compensation, circulating characteristics of 3P4W MMC-DSTATCOM are different from conventional MMCs. Moreover, distinct working principle MMC would...

Indenoisoquinolines are topoisomerase I (Top1) inhibitors developed to overcome some of the limitations of camptothecins and expand their anticancer spectrum. NSC 727357 is a novel dimeric indenoisoquinoline derivative with potent antiproliferative activity in the NCI-60 cell line panel, promising hollow fiber activity (score = 32) and activity against xenografts. Submicromolar concentrations o...

The proliferative response of neural stem cells (NSCs) to folate may play a critical role in the development, function and repair of the central nervous system. It is important to determine the dose-dependent effects of folate in NSC cultures that are potential sources of transplantable cells for therapies for neurodegenerative diseases. To determine the optimal concentration and mechanism of a...

Cdc25 phosphatases are important in cell cycle control and activate cyclin-dependent kinases (Cdk). Efforts are currently under way to synthesize specific small-molecule Cdc25 inhibitors that might have anticancer properties. NSC 95397, a protein tyrosine phosphatase antagonist from the National Cancer Institute library, was reported to be a potent Cdc25 inhibitor. We have synthesized two hydro...

Objective: Assessment of functional recovery of neural stem cells (NSCs) and (-)-deprenyl, in a contusive spinal cord injury model in rats. Materials and Methods: A total of 24 female Sprague Dawley rats were randomly, but equally (n=6), allocated into the following groups: control, sham, NSC graft and NSC graft + (-)-deprenyl. All animals were laminectomized at the T13 level. Contusion was per...