OBJECTIVE To examine the relation of fatty acid-binding protein (FABP)4 and nonesterified fatty acids (NEFAs) to diabetes in older adults. RESEARCH DESIGN AND METHODS We ascertained incident diabetes among 3,740 Cardiovascular Health Study participants (1992-2007) based on the use of hypoglycemic medications, fasting glucose ≥ 126 mg/dL, or nonfasting glucose ≥ 200 mg/dL. FABP4 and NEFA were ...

Long-term administration of PUFA is known to modulate immune functions and apoptotic pathways depending on the respective amount of n-6 and n-3 fatty acids (FA). Data on short-term effects on apoptotic pathways are rare. Apoptosis of splenic lymphocytes is the hallmark of detrimental sepsis. Therefore, we aimed to compare the immediate effects of parenterally administered n-6-enriched soyabean ...

OBJECTIVE To assess insulin action on peripheral glucose utilization and nonesterified fatty acid (NEFA) suppression as a predictor of coronary artery calcification (CAC) in patients with type 1 diabetes and nondiabetic controls. RESEARCH DESIGN AND METHODS Insulin action was measured by a three-stage hyperinsulinemic-euglycemic clamp (4, 8, and 40 mU/m²/min) in 87 subjects from the Coronary ...

29 Insulin administration during insulin-modified intravenous glucose tol30 erance test (IM-IVGTT) can induce transient hypoglycemia in healthy 31 insulin-sensitive subjects. This triggers counterregulatory responses (CRR), 32 which influence the kinetics of glucose and non-esterified fatty acids (NEFA) 33 and undermines the accuracy of mathematical modeling methods that do 34 not explicitly ac...

u çalışmada holştayn ırkı düvelerde yaşamın 9. ayından başlanarak gebeliğin belirlendiği zamana kadar rasyona rumen korumalı lizin ve metiyonin ilavesinin bazı kan metabolizma parametreleri üzerine etkileri incelenmiştir. Bu amaçla 40 adet sağlıklı 9 aylık yaşı doldurmuş (9-10 ay arası) düveler rastgele örnekleme metodu K (Kontrol) U (Uygulama) olmak üzere 2 gruba ayrılmıştır. Kontrol grubundak...

The aim of the present study was to investigate blood parameters and subsequent fertility in cows with or without increased postpartum polymorphonuclear neutrophil activity. conducted 15 Brown Swiss between 1-3 lactations. Polymorphonuclear activities were assessed at 10±4 days before after parturition. which maintained their phagocytic oxidative burst activites compared prepartum period classi...

Studies with teleost larvae have reported poor performance associated with quantitative lipid imbalances in the diet. The present study examined the effect of dietary protein:neutral lipid ratio on fatty acid (FA) absorption efficiency and metabolism in larval Senegalese sole. In addition, the effect of lipid class (triolein (TRI) and l-3-phosphatidylcholine-1,2-di-oleoyl (PC)), carbon number a...

Among the strongest of the many risk markers for coronary heart disease (CHD) are elevated concentrations of blood lipids, cholesterol and (more controversially) triacylglycerol (TAG). It is not usual to associate increased concentrations of another plasma lipid constituent, the non-esterified fatty acids (NEFAs), with increased risk of cardiovascular disease. In fact, the condition is not even...

Low-fat, high-carbohydrate (LF/HC) diets commonly elevate plasma triglyceride (TG) concentrations, but the kinetic mechanisms responsible for this effect remain uncertain. Subjects with low TG (normolipidemic [NL]) and those with moderately elevated TG (hypertriglyceridemic [HTG]) were studied on both a control and an LF/HC diet. We measured VLDL particle and TG transport rates, plasma nonester...

Based on their proposed metabolic effects, we examined whether fish oil (FO) and SCFA, alone or in combination, accelerate weight loss and the resultant metabolic improvements. Obesity was induced in male C57BL/6J mice by high-energy feeding for 10 weeks. The mice were transferred to a low-fat diet (2·5w%) for 4 weeks, the source of fat being either FO, a lard-safflower oil mix (control), or bo...