In cystic fibrosis (CF), repeated inflammation of the lung leads to progressive damage of lung tissue [1, 2]. In case of tissue destruction or in response to inflammation, necrotic cells release danger signals. These proteins trigger inflammatory responses, contribute to elimination of pathogens and induce tissue repair [3]. Imbalanced or uncontrolled release of such mediators may amplify infla...

BACKGROUND AND PURPOSE Positron emission tomography (PET) provides quantitative metabolic information and potential biomarkers of treatment outcome. We aimed to determine the prognostic value of early 18F-fluoroethyl-tyrosine (18F-FET) PET scans acquired during re-irradiation for recurrent high-grade glioma (HGG). MATERIAL AND METHODS A phase I clinical trial of re-irradiation of HGG was carr...

We retrospectively evaluated the usefulness of combined measurement of L-methyl-[11C]methionine (MET) and 3'-deoxy-3'-[18F]fluorothymidine (FLT) positron emission tomography (PET) in the differential diagnosis between recurrent gliomas and necrotic lesions. Twenty-one patients with high-grade glioma, previously treated with surgery and radiotherapy with chemotherapy and first radiological suspi...

Eosinophils (Eos) are found at increased numbers within necrotic areas of tumors. We show that necrotic material from cell lysates containing damage-associated molecular pattern molecules induce eosinophil degranulation (release of major basic protein and eosinophil peroxidase) and enhance their oxidative burst while the stimulatory capacity of cell lysates is significantly diminished following...

The lungs are a common site of metastases from malignant tumors. Their removal with minimal but safe tissue margin is essential for the long-term survival patients. aim this study was to evaluate usefulness 1940 nm thulium-doped fiber laser (TDFL) and 1470 diode (DL) in pig model lung surgery that involved incision excision tissue. Histopathological analysis performed on days 0 7 after surgery....

BACKGROUND Measures of tumor vascularity and hypoxia have been correlated with glioma grade and outcome. Dynamic contrast-enhanced (DCE) MRI can noninvasively map tumor blood flow, vascularity, and permeability. In this prospective observational cohort pilot study, preoperative imaging was correlated with molecular markers of hypoxia, vascularity, proliferation, and progression-free and overall...

BACKGROUND Both the progression of diabetic kidney disease and increased glycemic variability play important roles in the pathogenesis of coronary plaque formation via inflammatory pathways in patients with type 2 diabetes mellitus (T2DM). Therefore we evaluated the role of renal function in the contributory effects of blood glucose fluctuations and blood levels of inflammatory cytokine concent...

Glioblastoma multiforme; Necrotic focus; Vasogenic edema; Bilateral filter; Contrast limited adaptive histogram equilization Abstract This paper does the qualitative comparison of Fuzzy C-means (FCM) and k-Means segmentation, with histogram guided initialization, on tumor edema complex MR images. The accuracy of any segmentation scheme depends on its ability to distinguish different tissue clas...

In this study, we explored whether topical application of antibodies targeting tumor necrosis factor-α (TNF-α) or interleukin-6 (IL-6) conjugated to hyaluronic acid (HA) could reduce the extension of necrosis by modulating inflammation locally in a partial-thickness rat burn model. Partial-thickness to deep partial-thickness burn injuries present significant challenges in healing, as these burn...

Facial hemangiomas are benign vascular neoplasms of infancy and childhood. Although most hemangiomas do not result in significant complications, some result in pain, ulceration, infection, and structural abnormalities and can interfere with respiration, vision, and hearing. A 5-month-old infant presented to the author's wound center with a necrotic wound within a large, segmental hemangioma of ...