A morphometric procedure yielding dependable quantita tive data on structural components of tumors was devised. Semiquantitative data on necrobiosis, karyorrhexis, and infiltrating inflammatory cells were also obtained. Sections of tumor cut in three mutually perpendicular directions revealed minor quantitative intratumor variation for smallcell and epidermoid carcinoma but greater ones for ade...

A skin lesion previously unassociated with Crohn's disease is described. Although superficially resembling erythema nodosum it runs a different clinical course and has different histological appearances, the central feature being necrobiotic collagen. The term ;nodular necrobiosis' is suggested.

The case of a 52-yr-old female with rheumatoid arthritis and HIV who developed massive, progressive, cavitary pulmonary nodules is described. Multiple diagnostic bronchoscopies and lung biopsies failed to demonstrate the presence of any microorganisms. Pathological analysis showed palisading histiocytes with necrobiosis consistent with rheumatoid nodules. The effect of co-existing HIV infection...

A 60-year-old man with destructive rheumatoid disease, multiple nodules, and vasculitis developed a facial rash with ulceration and scarring. Histology showed granulomatous vasculitis. The rash was rapidly controlled with oral corticosteroids. Granulomatous vasculitis has not previously been reported as causing this clinical picture in the absence of concomitant necrobiosis and palisading.

1 Ferguson A, Ziegler K. Intraepithelial lymphocyte mitosis in a jejunal biopsy correlates with intraepithelial lymphocyte count, irrespective of diagnosis. Gut 1986; 27: 675-9. 2 Niazi NM, Leigh RJ, Crowe P, Marsh MN. Morphometric analysis of small intestinal mucosa. I Methodology, epithelial volume compartments and enumeration of inter-epithelial space lymphocytes. Virchows Archiv [Pathol Ana...