Inhalation of hypertonic saline aerosol is a relatively noninvasive method to obtain sputum for examination of inflammatory processes in the airways. We investigated some technical factors which might influence the success of induction and sputum cell counts. In total, twenty six asthmatic and 13 healthy subjects, unable to raise sputum spontaneously, inhaled nebulized saline for three 7 min in...

BACKGROUND The position of the jet or ultrasonic nebulizer in the ventilator circuit impacts drug delivery during mechanical ventilation, but has not been extensively explored, and no study has examined all of the commonly used nebulizers. METHODS Drug delivery from jet, vibrating-mesh, and ultrasonic nebulizers and pressurized metered-dose inhaler (pMDI) with spacer was compared in a model o...

OBJECTIVES We evaluated the suitability of an aminosterol derivative (ASD), possessing interesting in vitro antimicrobial activities against various resistant pathogens involved in lung infections of cystic fibrosis patients, for aerosol drug delivery. METHODS The suitability of 2 and 10 mg/mL ASD solutions for aerosol delivery was evaluated and compared with that of a commercial inhalable so...

The delivery of an aerosolized drug to a child is a complex process requiring an interaction between parent, child, and inhalation device. Recent studies have shown that the facemask can be a key factor affecting aerosol delivery, particularly the influence of leaks between the facemask and the face. To further quantify these effects and design around them, we have developed a bench model consi...

Respiratory disorders are very prevalent and high-incidence group of diseases having severe impacts on humanhealth in the world. Some respiratory difficult to diagnose treat, such as chronicobstructive pulmonary disease, asthma, lungs cancer, tuberculosis. Lungs cancer is secondmost common globally. Nano-delivery technologies have a great potential improve drug targetingin specific area infecti...