We have isolated a cardiac natriuretic peptide of 5,000 d from atrial tissues from 500 rats and determined its amino acid sequence. The 5,000 d atrial natriuretic factor was elucidated to be a 45 amino acid peptide with the sequence of S-Q-D-S-A-F-R-I-Q-E-R-L-R-N-S-K-M- A-H-S-S-S-C-F-G-Q-K-I-D-R-I-G-A-V-S-R-L-G-C-D-G-L-R-L-F by sequencing the native peptide and its lysyl endopeptidase digests. ...

Many studies have described the role of B-type natriuretic peptide or its amino-terminal byproduct (NT-pro-B-type natriuretic peptide) in clinical practice, including several published or ongoing randomized clinical trials. However, the debate over natriuretic peptide testing continues, mostly related to the appropriateness of testing as decision support for the management of heart failure. The...

Many studies have described the role of B-type natriuretic peptide or its amino-terminal byproduct (NT-pro-B-type natriuretic peptide) in clinical practice, including several published or ongoing randomized clinical trials. However, the debate over natriuretic peptide testing continues, mostly related to the appropriateness of testing as decision support for the management of heart failure. The...

The aim of the study was to evaluate the clinical usefulness of N-terminal pro-brain natriuretic peptide (NT-Pro BNP) and nitric oxide (NO) with echocardiography (gold standard test) in diagnosis of canine cardiomyopathy. Out of 374 cases, 82 cases showing cardiovascular abnormalities including 16 cases of cardiomyopathy were further selected for standardization of biomarkers. Significant (P

The biological significance of atrial natriuretic peptide (ANP) has been studied exhaustively from a physiological, pathological, pharmacological, and diagnostic standpoint. This member of the natriuretic peptide family exerts a profile of complementary effects in the cardiovascular system, including natriuretic, diuretic, vasodilator, anti–renin–angiotensin–aldosterone system, antihypertrophic...

BACKGROUND AND PURPOSE Excessive production of nitric oxide (NO) by inducible NO synthase (iNOS) is thought to underlie the vascular dysfunction, systemic hypotension and organ failure that characterize endotoxic shock. Plasma levels of atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP) are raised in animal models and humans with endotoxic sho...