Aim: Chronic rhinosinusitis is an inflammatory disease of the nasal mucosa often occurring concurrently with dry eye. The aim was to assess the effects of Manuka (Leptospermum spp.) antibacterial honey nasal spray (Melcare® Manuka+TM Nasal Spray, Melcare, Australia) and eye drops (Optimel Manuka+ Dry Eye Drops, Melcare, Australia) on both conditions. The safety of and adherence to these treatme...

We previously demonstrated that 1-ethyl-2-benzimidazolone (1-EBIO) directly activates basolateral membrane calcium-activated K(+) channels (K(Ca)), thereby stimulating Cl(-) secretion across several epithelia. In our pursuit to identify potent modulators of Cl(-) secretion that may be useful to overcome the Cl(-) secretory defect in cystic fibrosis (CF), we have identified chlorzoxazone [5-chlo...

BACKGROUND Although antihistamines and topical corticosteroids are used in combination to treat allergic rhinitis, their additive effect has not been yet demonstrated. The aim was investigate the antiinflammatory additive effect of mometasone and desloratadine on cytokine and sICAM-1 secretion by epithelial cells, and on eosinophil survival stimulated by human epithelial cells secretions from n...

Eosinophils are involved in the initiation and propagation of diverse inflammatory responses, including antigen presentation and the release of proinflammatory cytokines, chemokines, lipid mediators and cytotoxic granules (1-4) (Fig. 1). Tissue damage and dysfunction resulting from secretion of these pleiotropic mediators is a common pathogenic component in several diseases, including atopic as...

jasminum amplexicaule buch.-ham. (oleaceae) has been commonly used in the traditional medicine in dysentery, diarrhoea and bellyache in china. in the present work, the methanol extract of jasminum amplexicaule (jme) was examined for pharmacology on human colonic epithelial cell line t84 by the short-circuit current technique. the results showed that pretreatment of t84 cells with jme produced a...

Pliable diagnostic findings, e.g. canalicular optic neuritis and ?ther peripheral neuritis, rheumatoid arthritis, neurasthenia, Cental depression and even insanity. The existence of frontal sinusitis in doubtful cases may dually be diagnosed by means of good skiagrams and ^rther corroborated by passing a fine cannula into the sinus blowing air so as to cause any secretion from the sinus *? appe...

objective: acinetobacter baumannii (a. baumannii) has a good potential to colonize on various surfaces. as a virulence factor, adhesion to surfaces is the first step in colonization. the two-partner secretion system (tps) proteins are key factors for bacterial attachment. the purpose of this study is to identify and study the role of this family of proteins in adhesion of a. baumannii to human ...