Mucoadhesive delivery systems offer several advantages over other oral controlled release systems by virtue of prolongation of residence time of drug, its targeting, and localization of the dosage form at a specific site. These advantages include bypass of first pass metabolism of the drug and hence more concentration of the drug is available for absorption. Mucoadhesion occurs between two surf...

Successful treatment of inflammatory airway disease (IAD) requires environmental management to minimize exposure to irritants and combination drug therapy to reduce pulmonary inflammation and prevent bronchoconstriction. Aerosolized drug therapy is an efficient means of treatment for most horses with IAD. Aerosolized drug therapy has been standard treatment for human patients with non-infectiou...

Oxytocin (OT) in the central nervous system (CNS) influences social cognition and behavior, making it a candidate for treating clinical disorders such as schizophrenia and autism. Intranasal administration has been proposed as a possible route of delivery to the CNS for molecules like OT. While intranasal administration of OT influences social cognition and behavior, it is not well established ...

conventional transdermal drug delivery systems (tdds) have been designed for drug delivery through the skin. these systems use the permeability property of stratum corneum, the outermost surface layer of the skin. applying polymeric micro and nanofibers in drug delivery has recently attracted great attention and the electrospinning technique is the preferred method for polymeric micro-nanofiber...

chitosan with excellent biodegradable and biocompatible characteristics has received attention as an oral drug delivery vehicle for controlled-release formulations. in this study an enteric-coated capsule containing theophylline-chitosan beads based on 23 factorial designs was prepared as a colon drug delivery system. the theophylline-chitosan gel beads were formulated by adding the drug-contai...

niosomes, non-ionic surfactant vesicles (nsvs), are the hydrated lipids composed mainly of different classes of non-ionic surfactants, introduced in the seventies as a cosmetic vehicle. nowadays, niosomes are used as important new drug delivery systems by many research groups and also they are effective immunoadjuvants which some commercial forms are available in the market. these vesicles rece...

carbon nanotubes (cnts) are high aspect ratio allotropes of carbon. because of their unique physical and chemical characteristics, they are nominated for a vast variety of applications in the biomedical field. their very low solubility is the only problem of them which is solved by different methods of functionalization. after discoveries in the last few years of the capacity of cnts to penetra...

in this work we synthesized of mesoporous silica nanoparticles and functionalized with 3-aminopropyltriethoxysilane to improve the loading and release of ibuprofen bonded to 3-aminopropyltriethoxysilane. sample were characterized by fourier transform infrared spectroscopy, scanning electron microscopy , x-ray diffraction, and ultraviolet-visible. the fourier transform infrared spectroscopy resu...

topical and transdermal drug delivery systems are noninvasive and can be self-administered with the minimization of side-effects, have received increased attention during the past few years. nanoemulsions, emulsions sized between 20-200 nm with narrow distributions, offer several advantages for topical and transdermal delivery of pharmaceutical agents including controlled droplet size, the abil...

recently, specific attention has been paid to aptamers, short dna or rna, as a tool for cancer diagnosis and therapy. in the present study mcs nanogels were prepared by myristate: chitosan at 1:9 ratio and were characterized by several techniques. a selected ssdna aptamer(apt) capable of detecting lncap cells was linked to myristilated chitosan nanogels (apt-mcs) by glutaraldehyde and loaded wi...