Aptamer-protein conjugation inside a confined environment generates a non-homogeneous fixed charge distribution, leading to the emergence of ionic current rectification characteristics in single cylindrical nanopores.

We demonstrate that colloidal lithography with self-assembled monolayers of crosslinkable polymeric particles can be used to create hierarchical arrays of nanopores on substrates.

The transport of molecules through nanoscale confined space is relevant in biology, biosensing, and industrial filtration. Microscopically modeling nanopores required for a fundamental understanding guiding engineering, but the short duration low replica number existing simulation approaches limit statistically insight. Here we explore protein with high-throughput computational method that real...

Enzyme-catalyzed reactions inside nanoconfined geometries promote sensitive changes in the surface charge polarity and the concomitant permselective transport properties of the single conical nanopores.

Solid-state nanopore sensors are highly versatile platforms for the rapid, label-free electrical detection and analysis of single molecules, applicable to next generation DNA sequencing. The versatility of this technology allows for both large scale device integration and interfacing with biological systems. Here we report on the development of a hybrid biological solid-state nanopore platform ...

Nanometer-sized pores can be used to detect and characterize biopolymers, such as DNA, RNA, and polypeptides, with single-molecule resolution. Experiments performed with the 1.5 nm pore a-hemolysin (a-HL) demonstrated that singlestranded DNA and RNA molecules can be electrophoretically threaded through a pore, and that the ion current flowing through the pore contains information about the biop...