Mesoporous silica nanoparticles (MSNs) have garnered a great deal of attention as potential carriers for therapeutic payloads. Here, we report a pH-responsive drug-carrier based on chondroitin sulfate functionalized mesostructured silica nanoparticles (NMChS-MSNs) ie, the amidation between NMChS macromer and amino group functionalized MSNs. The prepared nanoparticles were characterized using dy...

Let s ? 3 $s \geqslant 3$ be a natural number, let ? ( x ) $\psi (x)$ polynomial with real coefficients and degree d 2 $d 2$ , A $A$ some large, non-empty, finite subset of numbers. We use E $E_{s,2}(A)$ to denote the number solutions system equations ? i = 1 ? + 0 \begin{equation*}\hskip2.5pc \sum _{i=1}^{s} (\psi (x_i) - \psi (x_{i+s}) )= (x_i x_{i+s} 0, \end{equation*} where ? $x_i \in A$ fo...

Development of successful formulations for poorly water-soluble drugs remains a longstanding critical and challenging issue in cancer therapy. As a potential drug carrier of paclitaxel, hydrotropic oligomer-glycol chitosan (HO-GC) was synthesized by chemical conjugation of the N,N-diethylnicotinamide-based oligomer, uniquely designed for enhancing the aqueous solubility of paclitaxel, to the ba...

Atomistic and meso scale computer simulations of nanoparticle aggregation are combined to describe the self-assembly of supraparticles in bulk and on surfaces under vacuum conditions. At the nano scale, atomic resolution molecular dynamics simulations provide the structures of 30 nm-diameter nanoparticles bound to each other and to coated hydrophobic surfaces, through the physical contacting of...

Gold nanoparticles with exotic shapes, such as triangle, pentagon, and hexagon, have been synthesized by glow discharge in aqueous solutions. A pulsed power supply was used to generate discharges in the aqueous solutions. Pulse width and frequency were 2 s and 15 kHz, respectively. Discharges were generated at applied voltages of 1600 and 3200 V. The shapes of the gold nanoparticles and electro...

Polyelectrolyte-coated nanoparticles or microparticles interact with bioactive molecules (peptides, proteins or nucleic acids) and have been proposed as delivery systems for these molecules. However, the mechanism of adsorption of polyelectrolyte onto particles remains unsolved. In this study, cationic poly(lactide-co-glycolide) (PLGA) nanoparticles were fabricated by adsorption of various conc...

Carbon nanoparticles have recently drawn intense attention in biomedical applications. Hence, there is a need for further in vivo investigations of their biocompatibility and biodistribution via various exposure routes. We hypothesized that intraperitoneally injected diamond, graphite, and graphene oxide nanoparticles may have different biodistribution and exert different effects on the intact ...

Chronic intracellular infections caused by drug-resistant pathogens pose a challenge to the treatment of chronic osteomyelitis. Such treatment requires an intracellular delivery system for the sustained release of antibiotics such as vancomycin (VCM), which is an antibiotic of last resort used against many clinically resistant bacteria. In this work, we report VCM-loaded N-trimethyl chitosan (T...

Silicon nanoparticles have important applications, including nonvolatile floating-gate memory devices. To prevent device performance variations, particle size and oxide thicknesses need to be controlled with a high degree of precision. Additionally, producing well-ordered, two-dimensional arrays of nanoparticles may require the exploitation of self-assembly techniques and colloidal forces, whic...