Skin is an important organ of the body due to offering an accessible and convenient site for drug administration. One of the disadvantages of transdermal drug delivery is the low penetration rate of drugs through the skin. Over the past decades, nanoparticles have been used as drug delivery systems to increase therapeutic effects or reduce toxicity. Encapsulation of drugs in nanoparticulate ves...

Objective(s): Omega-3 fatty acids play a key role in maintaining human health. The present study aimed to reduce the fishy smell and taste of omega-3 fatty acids through the encapsulation of lipid vesicles. Materials and Methods: Different non-ionic surfactants from the sorbitan ester family and egg lecithin with cholesterol were utilized to form micro-niosomal and liposomal formulations ...

Vesicular system drug design has revitalised the efficacy of previous medications by effectively regulating and sustaining their therapeutic action. The objective this study is to evaluate feasibility utilizing pharmaceutical interventions target novel vesicular delivery systems. innovative medication administration minimize adverse effects while ensuring at a predetermined or reasonably consis...

Proniosomal drug delivery system is a stable provesicular in nanotechnology to overcome the drawbacks associated with other vesicular systems. These are water-soluble pro-vesicular carriers coated non-ionic surfactant which on hydration give niosomes. The encapsulated and shows systemic targeted of poorly soluble drugs increased bioavailability decreased side effects. Here we have covered chara...

Frederick Banting and Charles Best extracted insulin from bovine pancreas in 1922, who received the Nobel Prize for their contribution in Medical field with John McLeod. Conventional insulin treatment involves replacement therapy, which involves the administration of insulin exogenously via subcutaneous route to mimic the pancreatic insulin secretion. Many people with types 1 and 2 diabetes ove...

Background/aim: Methotrexate (MTX) is a folic acid antagonist that widely used to treat osteosarcoma, leukemia, breast cancer, and autoimmune inflammatory diseases. The most important concerns with MTX are its poor solubility high toxicity, particularly in liver cells. To enhance minimize we encapsulated niosomes investigated hepatotoxicity mechanisms using genetic biomarkers. Materials methods...