OBJECTIVES Causality of occurrence of metformin-associated lactic acidosis (MALA) is a clinical problem. Currently, there is no drug available to prevent MALA. The present study was conducted to evaluate the protective effect of Berberine (BBR) against MALA in induced diabetic rat model. MATERIALS AND METHODS A sample of 75 healthy male Wistar rats was randomly selected according to inclusion...

The aquaporin5 (AQP5) is an integral membrane protein that plays an important role in maintaining water homeostasis in the lung during of puberty. The purpose of this study was to evaluate the effect of period of reduced training with Nigella Sativa (NS) supplementation on AQP5 levels in the lung of Male Wistar rats during of puberty. 110 newborn three-week old male Wistar rats with average wei...

background & aim: this study evaluated prevention effect of hydro-alcoholic extract of punica granatum peel ethylene glycol-induced nephrolithiasis in wistar rats. experimental: 20 male wistar rats were randomly divided into 4 equal groups. group i animals served as normal control (a) and received distilled water for 28 days. group ii to iv animals received 1% v/v ethylene glycol (eg) in d...

objective(s): 3, 4-methylenedioxymethamphetamine (mdma) one of the methamphetamine derivatives that affect the reproductive system, has not been well understood. many young people are consumers of drugs such as mdma that can affect their reproductive capability. apoptosis is the main mechanism for male infertility. pentoxifylline (ptx) increases camp intracellularly and reduces tumor necrosis f...

Lead reproductive toxicity has been reported in men. Nigella sativa seed and its active component, thymoquinone have used traditional pharmacopeia as natural remedy to promote health. This study investigated the ameliorative potential of Thymoquinone (TQ) on male functions lead acetate (PbA)-induced Wistar rats. Thirty rats weighing 100–120 g were randomly divided into six groups (n=5); Control...

Exercise can ameliorate cardiovascular dysfunctions in the diabetes condition, but its precise molecular mechanisms have not been entirely understood. The aim of present study was to determine impact endurance training on expression angiogenesis-related genes cardiac tissue diabetic rats. Thirty adults male Wistar rats were randomly divided into three groups (N = 10) including (DT), sedentary (...

Objective(s): Causality of occurrence of metformin-associated lactic acidosis (MALA) is a clinical problem. Currently, there is no drug available to prevent MALA. The present study was conducted to evaluate the protective effect of Berberine (BBR) against MALA in induced diabetic rat model. Materials and Methods: A sample of 75 healthy male Wistar rats was randomly selected according to inclusi...

The purpose of this study was to investigate the effects two different acute stress protocols, such as restraint and cold stress, on coagulation indicators in rats. conducted 18 male Wistar albino rats aged 8-10 weeks with a body weight 180-220 g. After one-week adaptation period, were randomly divided into three groups (n=6/group). animals control group not exposed any stress. Rats housed rest...

Diclofenac sodium (DF) is a non-steroidal anti-inflammatory drug (NSAID) that possesses antipyretic, analgesic, antinociceptive and activities. Like other NSAIDs, DF known to be associated with renal, cardiovascular, gastrointestinal complications. The present study was carried out evaluate the adverse effects of in vivo wistar albino rats assess if oral administration organic osmolyte betaine ...