Allen, K. V., I. S. McGregor, et al. (2003). "Regional differ Delta(9)-THC induced Fos expression in rat brain." Neuropharm Recent behavioral and pharmacological research sh cannabinoid and opioid neurochemical systems. Here we exam this interaction using c-fos immunohistochemistry. We compare of male albino Wistar rats treated with vehicle, Delta(9)-tetrah i.p.), naloxone (10 mg/kg, i.p.) or T...

OBJECTIVE To present a case of ventricular tachycardia following naloxone administration and to review current literature concerning ventricular tachycardia associated with naloxone. METHODS We present a case and review the literature concerning ventricular tachycardia (VT) as a complication of naloxone administration. RESULTS In our patient, a 44-year old male intoxicated multi-drug user, ...

Toll-like receptor 4 (TLR4) activation by bacterial infection, or by sterile inflammatory insult is a primary trigger of spontaneous preterm birth. Here we utilize mouse models to investigate the efficacy of a novel small molecule TLR4 antagonist, (+)-naloxone, the non-opioid isomer of the opioid receptor antagonist (-)-naloxone, in infection-associated preterm birth. Treatment with (+)-naloxon...

This study examined whether activation of extracellular signal-regulated kinase (ERK) contributes to the increased open-arm time observed in the elevated plus maze (EPM) during opioid withdrawal. We applied SL327, a selective ERK kinase (MEK) inhibitor, to specific limbic areas and examined the effect on EPM behaviors of controls and during naloxone-precipitated morphine withdrawal. We next con...

The present study was designed to assess the influence of magnesium (Mg) as MgCl(2) (10 or 40 mg/kg b.wt/day i.p.) and of its interaction with morphine on the reward system (RS) in Wistar rats. For this purpose, we evaluated conditioning place preference on a 12 day experiment schedule. Our data show that MgCl(2) (10 mg/kg b.wt/day) has moderate but significant effects on stimulating RS (increa...

Buprenorphine is used as a sublingual medication in the treatment of opioid dependence. However, its misuse by i.v. injection may limit its acceptability and dissemination. A buprenorphine/naloxone (ratio 4:1) combination has been developed to reduce diversion and abuse. So far, the relevance of this combination has not been investigated in the animal models traditionally used to study the rein...

There is growing evidence that tonic activity of the opioid system may be important in the modulation of affective state. Naloxone produces a conditioned place aversion in rodents, an effect that is centrally mediated. Previous pharmacological data using antagonists with preferential actions at mu-, delta-, and kappa-opioid receptors indicate the importance of the mu-opioid receptor in mediatin...