Abstract: Aim: To develop hydrogel films for hydrophilic drug delivery with citric acid-cross-linked Hydroxypropyl Methylcellulose (HPMC) and (MC). Materials Methods: The existing study is concerned the development of HPMC/MC employing acid as a cross-linking agent in order to accomplish loading while simultaneously releasing drugs (ciprofloxacin hydrochloride). Thermal analysis ATR-FTIR spectr...

A simple, precise and low cost conductometric method for the determination of alfuzosin hydrochloride and fexofenadine hydrochloride in pure form and pharmaceutical formulations using sodium tetraphenylborate has been described. The method is based on the formation of ion association complex of cations coming from the cited drugs with tetraphenylborate anions and the conductance of the solution...

Nutritional studies were performed on nine Bacteroides strains, by use of the methodology and media of anaerobic rumen microbiology. Ristella perfoetens CCI required l-arginine hydrochloride, l-tryptophan, l-leucine, l-histidine hydrochloride, l-cysteine hydrochloride, dl-valine, dl-tyrosine, and the vitamin calcium-d-pantothenate, since scant turbidity developed in media without these nutrient...

The chemical name of cetirizine hydrochloride is (±)-2-[2-[4-(4-chlorophenyl) phenylmethyl]-1-piperazinyl] ethoxy acetic acid dihydrochloride (C21H25ClN2O3•2HCl). Cetirizine hydrochloride is an antihistamine with selective antagonism to H1 receptors. Characterized by rapid onset, long duration of action and good safety, it is now a clinical medicine of autonomous production commonly used in Chi...

INTRODUCTION Anti-oxidant activities of adrenergic β-blockers are proposed in various organs. The aim of the present study was to investigate the effect of carteolol hydrochloride, an adrenergic β-blocker, on the production of reactive oxygen species (ROS) and the viable cell number after ultraviolet irradiation of cultured lens epithelial cells (LECs). MATERIALS AND METHODOLOGY Cultured LECs...

The paper deals with the development of a rapid and efficient Capillary Zone Electrophoresis (CZE) method for Quality Control analysis of pharmaceutical preparations containing antihistamines, decongestants, anticholinergic remedies and preservatives. Active ingredients of interest are: ChlorPheniramine Maleate (CPM), DiPhenhydramine Hydrochloride (DPH), Ephedrine hydrochloride (E), Isopropamid...

Flunarizine hydrochloride, a piperazine derivative, is a selective Ca channel blocker coupled with its antihistaminic property claimed to be effective in prophylaxis of migraine. Oral bioavailability of Flunarizine hydrochloride is very low (less then 18%) due to poor water solubility and extensive first pass metabolism. Hence the aim of the present study was to develop Flunaruzine hydrochlorid...

Background: The present work was undertaken with the aim to develop and validate a rapid and consistent RP-HPLC method in which the peaks will be appear with short period of time as per ICH Guidelines. Materials and Methods: The separation was achieved on a a stainless steel analytical column, Eclipse XDB plus C18 column (4.6 X 150 mm; 5 μm) in an isocratic mode. The mobile phase w...

Using first-order derivative techniques, a simple accurate and precise Ultraviolet spectrophotometric method was developed for the determination of solifenacin succinate tamsulosin hydrochloride in combined dosage form. Every solifinacin scanned wavelength region 200-400 nm sampling wavelengths selected were selected. Sampling chosen at 265 (zero crossing succinate) where absorbance important 2...