We measured [Ca]i and [Na ]i in isolated transgenic (TG) mouse myocytes overexpressing the Na -Ca exchanger and in wild-type (WT) myocytes. In TG myocytes, the peak systolic level and amplitude of electrically stimulated (ES) [Ca]i transients (0.25 Hz) were not significantly different from those in WT myocytes, but the time to peak [Ca]i was significantly prolonged. The decline of ES [Ca]i tran...

Rumpal, Nidhi and Gregory A. Lnenicka. Ca clearance at growth cones produced by crayfish motor axons in an explant culture. J Neurophysiol 89: 3225–3234, 2003; 10.1152/jn.00952.2002. Intracellular free Ca concentration ([Ca ]i) plays an important role in the regulation of growth cone (GC) motility; however, the mechanisms responsible for clearing Ca from GCs have not been examined. We studied t...

Introduction: In recent years, attraction toward drinking bottled mineral water has increased. Therefore, chemical composition and safety of these waters considering trace elements and heavy metals should confirm the national or international standard limits. The aim of this study was to evaluate and comparison of the mineral and heavy metal composition of bottled waters in Bandar Abbas with Ir...

Palmer, Bradley M., Joshua M. Lynch, Steven M. Snyder, and Russell L. Moore. Renal hypertension prevents run training modification of cardiomyocyte diastolic Ca21 regulation in male rats. J Appl Physiol 90: 2063–2069, 2001.—The combined effects of endurance run training and renal hypertension on cytosolic Ca21 concentration ([Ca]c) dynamics and Na-dependent Ca21 regulation in rat left ventricul...

Dog erythrocytes (RBC) have a system for passive Ca and Na movements that resembles the Ca-Na exchanger first described in cardiac muscle. Amrinone, a new cardiotonic drug active in humans with congestive heart failure, is shown to stimulate net Ca uptake by dog RBC. Amrinone's action is on Ca influx rather than efflux. The influence of Amrinone on Ca uptake is enhanced when the cells are place...

The Senegalese sole is a marine flatfish, which often penetrates into estuarine waters to feed. It cannot, however, survive in full freshwater. The current study investigated the effect of adaptation to low salinity (10 per thousand) on olfactory responses to changes in environmental [Ca(2+)] and [Na(+)] and amino acids by the electro-encephalogram (EEG) recorded from the olfactory bulb. The so...

One of the main aims of water resource planners and managers is to estimate and predict the parameters of groundwater quality so that they can make managerial decisions. In this regard, there have many models developed, proposing better management in order to maintain water quality. Most of these models require input parameters that are either hardly available or time-consuming and expensive to...

KB130015 [KB; 2-methyl-3-(3,5-diiodo-4-carboxymethoxybenzyl)benzofuran] is a novel amiodarone derivative designed to retain the antiarrhythmic effects without the side effects. Unlike amiodarone, KB slows Na(+) current inactivation and could, via an increase in [Na(+)](i), potentially lead to Ca(2+) overload. Therefore, we studied the effects of KB on Na(+) and Ca(2+) handling in single pig ven...

Reduction of the transsarcolemmal [Na] gradient in rabbit cardiac muscle leads to an increase in the force of contraction. This has frequently been attributed to alteration of Ca movements via the sarcolemmal Na/Ca exchange system. However, the specific mechanisms that mediate the increased force at individual contractions have not been clearly established. In the present study, the [Na] gradie...

Phosphorylation of Na channels has been suggested to increase their Ca permeability. Termed "slip-mode conductance" (SMC), this hypothesis predicts that Ca influx via protein kinase A (PKA)-modified Na channels can induce sarcoplasmic reticulum (SR) Ca release. We tested this hypothesis by determining if SR Ca release is graded with I(Na) in the presence of activated PKA (with Isoproterenol, IS...