the nosocomial infections, caused by multi-drug resistant bacteria, are the most important cause of mortality throughout the world. one important mechanism against beta-lactam antibiotics is the production of beta-lactamases. enterobacteriaceae and non-fermentative bacteria, like pseudomonas aeruginosa and acinetobacter baumannnii may produce these enzymes. currently, there is no vaccine to pre...

conclusions the findings of the present study well demonstrated that the p. aeruginosa biofilm-producing isolates were more resistant to the tested antibiotics. furthermore, because of wide distribution, it seems that the psla gene is associated with biofilm formation. results biofilm formation was observed in 70% of the p. aeruginosa isolates. the potential formation of biofilm was significant...

staphylococcus aureus, as one of the main agentsfor hospital infections,is considered as highly important because they show resistance to a wide range of antibiotics.resistance to selective antibiotics such as vancomycin is a serious problemin the medical community; thus it seems rational to use alternative substances for treating these bacteria.the aim of this study isto investigate the preval...

background: the frequency of the multi-drug resistance 1 (mdr1) gene c3435t polymorphism differs in various ethnical populations such as asian, african, and caucasians populations. a silent c3435t polymorphism in exon 26 of mdr1 has been reported to be associated with a decreased expression of p-gp in tt genotypes carriers compared with cc genotypes carriers. materials and methods: to evaluate ...

results analysis of the essential oil revealed the presence of pulegone (68.59%) piperitone (7.8%), piperitenone (7.8%), 1, 8-cineole (1.3%), and carvacrol (1.6%) as the major components. the results showed a significant activity against mdr a. baumannii with inhibition zones and minimal inhibitory concentration values in the ranges of 7-15 mm and 20-35 µl/ml respectively. conclusions this inve...

background: human immunodeficiency virus (hiv) makes infected cases prone to opportunistic infections like tuberculosis (tb) due to impaired immunity of the body, especially multi drug resistant (mdr) ones which are a major concern. with hiv outbreak starting late in the 20th century, the international health community is observing a huge rise in the incidence of this complex disease. herein, w...

abstract background and objective: streptococcus pneumoniae is the most common cause of acquired bacterial infections in the respiratory system. in recent years, a high incidence of pneumococcal resistance to different antibiotics has also been appeared. this study was conducted to evaluate the in vivo and in vitro resistance of pneumococcal pneumonia to ceftriaxone, azithromycin and co-amoxicl...

introduction: extended spectrum beta-lactamase (esbl) producing escherichia coli generate a major problem for clinical therapeutics and epidemiological study. the incidence of esbl producing strains among clinical isolates has been steadily increasing during the past few years, and remains an important cause of failure of therapy with cephalosporins. the aim of this study was to determine the a...

human immunodeficiency virus type 1 (hiv-1) protease inhibitors comprise an important class of drugs used in hiv treatments. however, mutations of protease genes accelerated by low fidelity of reverse transcriptase yield drug resistant mutants of reduced affinities for the inhibitors. this problem is considered to be a serious barrier against hiv treatment for the foreseeable future. in this st...

BACKGROUND The overall impact of influenza virus infection in immunocompromised patients is largely unknown. Antigenic drift and genetic variations during prolonged influenza infection have been demonstrated. In this report we describe a multidrug-resistant H3N2 influenza virus isolated from an immunocompromised patient after 5 days of therapy. METHODS Multiple nasal wash samples were collect...